ArticleBritish journal of pharmacology2000
Histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated action.
Article in British journal of pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Chronic sleep fragmentation enhances habenula cholinergic neural activity.Molecular psychiatry · 2021Article
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Potential Therapeutic Application for Nicotinic Receptor Drugs in Movement Disorders.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Review
- Histamine facilitates GABAergic transmission in the rat entorhinal cortex: Roles of HHippocampus · 2017Article
- Histamine and the striatum.Neuropharmacology · 2016Review
- Communication between mast cells and rat submucosal neurons.Pflugers Archiv : European journal of physiology · 2015Article
- Involvement of histaminergic inputs in the jaw-closing reflex arc.Journal of neurophysiology · 2015Article
- Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia.Neurobiology of disease · 2015Article
- Striatal cholinergic interneuron regulation and circuit effects.Frontiers in synaptic neuroscience · 2014Review
- Histamine and motivation.Frontiers in systems neuroscience · 2012Article
- TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell patch clamp recordings were made from rat striatal cholinergic interneurones in slices of brain tissue in vitro. Bath application of histamine (EC(50) 6.3 microM) was found to rapidly and reversibly depolarize these neurones through the induction of an inward current at -60 mV. 2. The effects of histamine were mimicked by the H(1) receptor agonist 2-thiazolylethylamine (50 microM) and selectively inhibited by pre-incubation with the H(1) receptor antagonist triprolidine (1 microM). 3. Ion substitution experiments under voltage clamp conditions revealed that the histamine activated current was comprised of two components. One component was sensitive to the concentration of extracellular Na(+), whilst the other component was inhibited by intracellular Cs(+) or extracellular Ba(2+). 4. In situ hybridization experiments revealed that the majority of cholinergic interneurones in the rat striatum express the histamine H(1) receptor but few neurones express H(2) receptors. These findings were confirmed using single cell RT - PCR. 5. It is concluded that histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.