ArticlePituitary1999
Prolactin-producing pituitary adenoma and carcinoma with neuronal components--a metaplastic lesion.
Article in Pituitary, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Co-expression of intermediate filaments glial fibrillary acidic protein and cytokeratin in pituitary adenoma.Pituitary · 2021Article
- Pituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region".The Journal of clinical endocrinology and metabolism · 2020Review
- Expression pattern of neuronal intermediate filament α-internexin in anterior pituitary gland and related tumors.Pituitary · 2015Article
- Pituitary adenoma with gangliocytic component: report of 5 cases with focus on immunoprofile of gangliocytic component.Pituitary · 2015Article
- Temozolomide in aggressive pituitary adenomas and carcinomas.Clinics (Sao Paulo, Brazil) · 2012Review
- Primary sellar neuroblastoma presenting with syndrome of inappropriate secretion of anti-diuretic hormone.Endocrine pathology · 2010Article
- Review
- Combined gangliocytoma and prolactinoma of the pituitary gland.Endocrine pathology · 2008Article
- Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: report of a case unassociated with radiotherapy.Endocrine pathology · 2004Review
- The differential diagnosis of lesions involving the sella turcica.Endocrine pathology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies indicate that cells of various epithelial tumors are capable of transformation to neurons. Observing both neurons and neuropil in two prolactin-producing adenohypophyseal tumors, one benign and one malignant, we sought to assess their cellular differentiation, the presence of nerve growth factor receptor, and expression of the dopamine receptor gene using immunocytochemistry, electron microscopy, and in situ hybridization. Light and electron microscopy clearly revealed cells morphologically transitional between adenoma/carcinoma cells and neurons. Large neurons lacked proliferative activity. Neurons in varying number showed immunoreactivity for pituitary hormones including prolactin, growth hormone and alpha subunit in the adenoma and prolactin alone in the carcinoma. The distribution of nerve growth factor receptor staining was similar. In both tumors, in situ hybridization showed mRNAs for prolactin and dopamine receptor within adenohypophyseal cells and neurons. Our results indicate that the occurrence of neurons and neuropil in growth hormone and prolactin-producing pituitary tumors appears to be the result of metaplasia. The process is not limited to benign tumors and may be due to the production of tropic substances by the adenohypophysial cells, which by paracrine/autocrine mechanisms result in transformation of adenoma cells to nerve cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.