Evidence map›Paper›PMID 11080266›Full record

Trial reportThe Journal of physiology2000

Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies.

C Malm, P Nyberg, M Engstrom, B Sjodin, R Lenkei, B Ekblom, I Lundberg

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02902315 (Vitamins C and E Combined With Cryotherapy on the Pain, Oxidative Stress and Inflammatory Response After Resistance Exercise Session in Untrained Volunteers), which is not on this map. Cited by 131 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 2 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02902315 nacompletednot on this mapstarted 2017, after this paper: background citation

Vitamins C and E Combined With Cryotherapy on the Pain, Oxidative Stress and Inflammatory Response After Resistance Exercise Session in Untrained Volunteers

TypeinterventionalSponsorUniversidade Federal de Santa MariaRan2017 to 2017Enrolled26ConditionsInflammation, Oxidative Stress, PainArmsCryotherapy, Vitamins C and E, Vitamins C and E associated with cryotherapy, Placebo
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 2 syntheses or guidelines pooled it, 383 citations in OpenAlex.

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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

C MalmDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. christer.malm@fyfa.ki.se
P Nyberg
M Engstrom
B Sjodin
R Lenkei
B Ekblom
I Lundberg
Karolinska Institutet · SESwedish School of Sport and Health Sciences · SESaint Göran Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. A role of the immune system in muscular adaptation to physical exercise has been suggested but data from controlled human studies are scarce. The present study investigated immunological events in human blood and skeletal muscle by immunohistochemistry and flow cytometry after eccentric cycling exercise and multiple biopsies. 2. Immunohistochemical detection of neutrophil- (CD11b, CD15), macrophage- (CD163), satellite cell- (CD56) and IL-1beta-specific antigens increased similarly in human skeletal muscle after eccentric cycling exercise together with multiple muscle biopsies, or multiple biopsies only. 3. Changes in immunological variables in blood and muscle were related, and monocytes and natural killer (NK) cells appeared to have governing functions over immunological events in human skeletal muscle. 4. Delayed onset muscle soreness, serum creatine kinase activity and C-reactive protein concentration were not related to leukocyte infiltration in human skeletal muscle. 5. Eccentric cycling and/or muscle biopsies did not result in T cell infiltration in human skeletal muscle. Modes of stress other than eccentric cycling should therefore be evaluated as a myositis model in human. 6. Based on results from the present study, and in the light of previously published data, it appears plausible that muscular adaptation to physical exercise occurs without preceding muscle inflammation. Nevertheless, leukocytes seem important for repair, regeneration and adaptation of human skeletal muscle.

Indexed as

AdultAntigensBicyclingBloodCatecholaminesC-Reactive ProteinCreatine KinaseExerciseFlow CytometryHormonesHumansHydrocortisoneImage Processing, Computer-AssistedImmunity, CellularImmunohistochemistryInterleukinsAntigensCatecholaminesC-Reactive ProteinCreatine KinaseHormonesHydrocortisoneInterleukins

Identifiers

PMID11080266
PMCPMC2270185
OpenAlexW1992958292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.