ArticleThe Journal of physiology2000
Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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Who cites it
132 citing papers in PubMed.
- Hypoxic conditioning in Parkinson's disease: randomized controlled multiple N-of-1 trials.Nature communications · 2025Trial
- Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.Experimental neurology · 2022Trial
- Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury.Experimental neurology · 2021Trial
- Long-term facilitation of ventilation in humans with chronic spinal cord injury.American journal of respiratory and critical care medicine · 2014Trial
- Long-term facilitation of ventilation following acute continuous hypoxia in awake humans during sustained hypercapnia.The Journal of physiology · 2012Trial
- Ampakine-hypoxia pairing reveals a novel NMDA-dependent respiratory neuroplasticity.Function (Oxford, England) · 2026Article
- Pairing ampakine with brief hypoxia evokes phrenic neuroplasticity via a spinal NMDA receptor-mediated mechanism.Function (Oxford, England) · 2026Article
- Beneficially Stressing the Peripheral Nervous System to Repair.International journal of molecular sciences · 2026Review
- Amino acid modulation of the carotid body selectively modulates peripheral chemoreceptor respiratory reflex.The Journal of physiology · 2026Article
- Intermittent phrenic afferent activation induces phrenic motor plasticity.Journal of neurophysiology · 2026Article
- Acute Adenosine Receptor Antagonism in Combination With Acute Intermittent Hypoxia to Promote Breathing Plasticity in Amyotrophic Lateral Sclerosis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled Trial.JMIR research protocols · 2025Article
- The development but not the maintenance of phrenic and sympathetic long-term facilitation after acute intermittent hypoxia requires nucleus tractus solitarii HExperimental neurology · 2025Article
- Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.Physiological reports · 2025Article
- Amplification of the therapeutic potential of AMPA receptor potentiators from the nootropic era to today.Pharmacology, biochemistry, and behavior · 2025Review
- Ventilatory long-term facilitation at rest increases the feedforward contribution to subsequent exercise ventilatory responses.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- AMPA receptors play an important role in the biological consequences of spinal cord injury: Implications for AMPA receptor modulators for therapeutic benefit.Biochemical pharmacology · 2024Review
- Review
- Sex differences in cardiac transcriptomic response to neonatal sleep apnea.Physiological reports · 2024Article
- The Effects of Volatile Anesthetics on Renal Sympathetic and Phrenic Nerve Activity during Acute Intermittent Hypoxia in Rats.Biomedicines · 2024Article
- Increased spinal adenosine impairs phrenic long-term facilitation in aging rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
1. Intermittent hypoxia elicits long-term facilitation (LTF) of phrenic motor output in anaesthetized rats. We tested the hypothesis that an equal cumulative duration of continuous hypoxia would not elicit phrenic LTF. 2. Integrated phrenic nerve activity was recorded in urethane-anaesthetized, vagotomized, paralysed and ventilated rats exposed to: (1) 3 X 3 min hypoxic episodes (inspired O2 fraction (FI, O2) = 0.11) separated by 5 min hyperoxia (FI,O2 = 0.5; n = 6), (2) 9 min continuous hypoxia (n = 6), or (3) 20 min continuous hypoxia (n = 7). Isocapnia was maintained throughout the protocol. 3. Consistent with previous studies, phrenic amplitude was significantly elevated for at least 1 h following intermittent hypoxia (78 +/- 15% 60 min post-hypoxia; P < 0.05) with an associated increase in burst frequency (11 +/- 2.1 bursts min-1; P < 0.05). In contrast, 9 or 20 min continuous hypoxia did not elicit LTF of either phrenic amplitude (4.7 +/- 5.1 and 10.1 +/- 10.2% 60 min post-hypoxia, respectively; P > 0.05) or frequency (4.6 +/- 1.3 and 5.1 +/- 2 bursts min-1 60 min post-hypoxia, respectively; P > 0.05). 4. The results indicate that hypoxia-induced long-term facilitation of phrenic motor output is sensitive to the pattern of hypoxic exposure in anaesthetized rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.