ArticleThe EMBO journal2000
Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 403 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
403 citing papers in PubMed, 956 citations in OpenAlex.
- A domestication-selected CIPK-MYB-HAK module improves salt tolerance in modern maize.Nature plants · 2026Article
- MYB Factors: Hubs of Plant Stress and Hormone Crosstalk.Plant biotechnology journal · 2026Review
- Article
- Ethylene-responsive CmERF3-CmMYB4 cascade suppresses anthocyanin biosynthesis inHorticulture research · 2026Article
- The FaDOF2-FaMYB4 transcriptional module regulates anthocyanin biosynthesis in strawberry fruit.Plant cell reports · 2026Article
- Transcription factor MdMYB6L represses anthocyanin biosynthesis of apple skin at low-altitude regions.Plant cell reports · 2026Article
- Article
- OsNAC10 negatively regulates salt tolerance by repressing OsHKT1;5 expression and reducing shoot-to-root NaPlant communications · 2026Article
- MaMYB12 and MaMYB308 antagonistically regulate flavonoid biosynthesis in mulberry (Food chemistry. Molecular sciences · 2026Article
- Integrated Metabolome-Transcriptome Profiling Identifies JrMYB8 as a Repressor of Polyphenol Biosynthesis in Walnut (Plants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of the R2R3-MYB family reveals potential regulators of lignin and tricin metabolism in the model grass Setaria viridis.Molecular genetics and genomics : MGG · 2026Article
- Article
- Metabolic engineering strategies for optimized lignan production in plants.Frontiers in plant science · 2026Review
- Genome-wide association studies of leaf photosynthetic gas exchange parameters in sugarcane.Frontiers in plant science · 2026Article
- Learning from nature: phytochemical strategies to protect against UV-B damage.Nature communications · 2025Review
- Identification and characterization of the gene OvANS associated with purple flower in Orychophragmus violaceus.BMC plant biology · 2025Article
- Genetic Regulation of Anthocyanin Biosynthesis inPlant direct · 2025Article
- Integrated transcriptome and metabolome analyses provide molecular insights into the transition of flower color in the rose cultivar 'Juicy Terrazza'.BMC plant biology · 2025Article
- Biosynthesis and Regulatory Mechanisms of Plant Flavonoids: A Review.Plants (Basel, Switzerland) · 2025Review
- Molecular underpinnings ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
343 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An Arabidopsis thaliana line that is mutant for the R2R3 MYB gene, AtMYB4, shows enhanced levels of sinapate esters in its leaves. The mutant line is more tolerant of UV-B irradiation than wild type. The increase in sinapate ester accumulation in the mutant is associated with an enhanced expression of the gene encoding cinnamate 4-hydroxylase, which appears to be the principal target of AtMYB4 and an effective rate limiting step in the synthesis of sinapate ester sunscreens. AtMYB4 expression is downregulated by exposure to UV-B light, indicating that derepression is an important mechanism for acclimation to UV-B in A.thaliana. The response of target genes to AtMYB4 repression is dose dependent, a feature that operates under physiological conditions to reinforce the silencing effect of AtMYB4 at high activity. AtMYB4 works as a repressor of target gene expression and includes a repression domain. It belongs to a novel group of plant R2R3 MYB proteins involved in transcriptional silencing. The balance between MYB activators and repressors on common target promoters may provide extra flexibility in transcriptional control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.