ArticleThe EMBO journal2000
Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 83 citations in OpenAlex.
- The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux.PloS one · 2025Article
- Rescuing lung development through embryonic inhibition of histone acetylation.Science translational medicine · 2024Article
- Analysis of the chromatin landscape and RNA polymerase II binding at SIN3-regulated genes.Biology open · 2023Article
- Coregulators Reside withinInternational journal of molecular sciences · 2023Article
- Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival.Biochimica et biophysica acta. Molecular cell research · 2022Article
- Hormone-dependent activation and repression of microRNAs by the ecdysone receptor in the dengue vector mosquitoProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.The Journal of biological chemistry · 2020Article
- Histone deacetylase 1 suppresses Krüppel homolog 1 gene expression and influences juvenile hormone action inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.Scientific reports · 2018Article
- Histone acetylation is involved in GA-mediated 45S rDNA decondensation in maize aleurone layers.Plant cell reports · 2018Article
- Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.The EMBO journal · 2017Article
- The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism.The Journal of biological chemistry · 2017Article
- The effects of Rpd3 on fly metabolism, health, and longevity.Experimental gerontology · 2016Review
- Inter-isoform-dependent Regulation of the Drosophila Master Transcriptional Regulator SIN3.The Journal of biological chemistry · 2016Article
- USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila.The Journal of biological chemistry · 2016Article
- Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms.BMC genomics · 2016Article
- The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.Epigenetics & chromatin · 2016Article
- Article
- The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development.Biology open · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylation of core histone N-terminal tails influences chromatin condensation and transcription. To examine how the SIN3-RPD3 deacetylase complex contributes to these events in vivo, we examined binding of SIN3 and RPD3 to Drosophila salivary gland polytene chromosomes. The binding patterns of SIN3 and RPD3 were highly coincident, suggesting that the SIN3-RPD3 complex is the most abundant chromatin-bound RPD3 complex in salivary gland cells. SIN3- RPD3 binding was restricted to less condensed, hypoacetylated euchromatic interbands and was absent from moderately condensed, hyperacetylated euchromatic bands and highly condensed, differentially acetylated centric heterochromatin. Consistent with its demonstrated role in transcriptional repression, SIN3-RPD3 did not co-localize with RNA polymer ase II. Chromatin binding of the complex, mediated by SMRTER, decreased upon ecdysone-induced transcriptional activation but was restored when transcription was reduced. These results implicate SIN3-RPD3 in maintaining histone acetylation levels or patterns within less condensed chromatin domains and suggest that SIN3-RPD3 activity is required, in the absence of an activation signal, to repress transcription of particular genes within transcriptionally active chromatin domains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.