ArticleThe EMBO journal2000
c-Myb regulates the proliferation of immature thymocytes following beta-selection.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- An overview of pim kinase as a target in multiple myeloma.Cancer medicine · 2023Review
- Metabolic regulation of T cell development.Frontiers in immunology · 2022Review
- The role of Pim kinase in immunomodulation.American journal of cancer research · 2020Review
- C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by AβJournal of molecular neuroscience : MN · 2017Article
- Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.Cancer discovery · 2016Article
- Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.The Journal of biological chemistry · 2013Article
- Review
- For better or for worse: the role of Pim oncogenes in tumorigenesis.Nature reviews. Cancer · 2011Review
- Article
- The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.Nature immunology · 2010Article
- Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Myb proteins regulate expression of histone variant H2A.Z during thymocyte development.Immunology · 2008Article
- Alu elements mediate MYB gene tandem duplication in human T-ALL.The Journal of experimental medicine · 2007Article
- Review
- c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.The EMBO journal · 2007Article
- c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression.Molecular and cellular biology · 2007Article
- Article
- Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.The EMBO journal · 2003Article
- The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transgenic mice expressing a T-cell-specific dominant interfering allele (MEnT) of the c-Myb transcription factor have a pronounced block in CD4(-)CD8(-) (DN) development. In this study we show that differentiation of DN MEnT thymocytes is blocked due to the failure of cells to enter the cell cycle following beta-selection, the process by which productive rearrangement of the T-cell receptor (TCR) beta-chain permits maturation of cells into CD4(+)CD8(+) (DP) thymocytes. c-myb mRNA continues to be expressed in DN cells in mice lacking a functional pre-TCR signalling pathway, implying that its transcriptional regulation is independent of the signalling events regulating beta-selection. It is also expressed in the absence of cytokine signalling. However, we show that c-Myb protein is required for the function in beta-selection of its known upstream activator, the serine/threonine kinase Pim1: MEnT expression inhibits the cell cycle in Pim1 transgenic DN thymocytes and prevents Pim1-mediated rescue of a RAG1(-/-) developmental block. Super activation of c-Myb by Pim1 may therefore be required for beta-selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.