ArticleProceedings of the National Academy of Sciences of the United States of America2000
Meiotic lamin C2: the unique amino-terminal hexapeptide GNAEGR is essential for nuclear envelope association.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Nucleoskeletal Proteins in Early Embryogenesis.Advances in experimental medicine and biology · 2026Review
- Review
- Article
- Article
- Expression of lamin C2 in mammalian oocytes.PloS one · 2020Article
- The Broad Spectrum ofFrontiers in physiology · 2020Review
- The Pathogenesis and Therapies of Striated Muscle Laminopathies.Frontiers in physiology · 2018Review
- Multi-target spectrally resolved fluorescence lifetime imaging microscopy.Nature methods · 2016Article
- Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements.Nucleus (Austin, Tex.) · 2015Review
- The myristoylated amino-terminus of an Arabidopsis calcium-dependent protein kinase mediates plasma membrane localization.Plant molecular biology · 2013Article
- The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.PLoS genetics · 2013Article
- Mechanism and a peptide motif for targeting peripheral proteins to the yeast inner nuclear membrane.Traffic (Copenhagen, Denmark) · 2009Article
- Protein SYCP2 provides a link between transverse filaments and lateral elements of mammalian synaptonemal complexes.Chromosoma · 2009Article
- Computational analysis of 3'-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat.Genome research · 2005Article
- Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes.Molecular biology of the cell · 2005Article
- Telomeres act autonomously in maize to organize the meiotic bouquet from a semipolarized chromosome orientation.The Journal of cell biology · 2002Article
- Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity.Nucleus (Austin, Tex.)Article
- Molecular characterization of Xenopus lamin LIV reveals differences in the lamin composition of sperms in amphibians and mammals.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic lamin C2 is the only A-type lamin expressed during mammalian spermatogenesis. Typical for this short lamin is the unique hexapeptide GNAEGR, which substitutes the nonhelical amino terminus and part of the alpha-helical rod domain present in somatic lamins. Meiotic lamin C2 also lacks a carboxyl-terminal CaaX box, which is modified by isoprenylation and involved in nuclear envelope (NE) association of somatic isoforms. The mechanism by which lamin C2 becomes localized in the NE is totally unknown. Here we demonstrate that the hexapeptide GNAEGR is essential for this process: (i) Its deletion resulted in a diffuse distribution of lamin C2 within nuclei of transfected COS-7 cells; (ii) Mutated somatic lamin C, containing the sequence GNAEGR at its amino terminus, was located at the NE. The mass spectrometric analysis of the amino terminus of lamin C2 revealed that it is modified by myristoylation. Correspondingly, the substitution of the first glycine residue abolishes the NE association of lamin C2. We conclude that NE association of lamin C2 is achieved by a mechanism different from that of somatic lamins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.