ArticleProceedings of the National Academy of Sciences of the United States of America2000
A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Cooperative Function of Atg8- and TORC1-Mediated Activities in Yeast.Yeast (Chichester, England) · 2025Article
- Histidine limitation alters plant development and influences the TOR network.Journal of experimental botany · 2025Article
- Transcription by the Three RNA Polymerases under the Control of the TOR Signaling Pathway inBiomolecules · 2023Review
- Review
- Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions.RNA biology · 2021Review
- Ccr4-Not as a mediator of environmental signaling: a jack of all trades and master of all.Current genetics · 2021Review
- The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity.PLoS genetics · 2020Article
- Mutations in the Arabidopsis ROL17/isopropylmalate synthase 1 locus alter amino acid content, modify the TOR network, and suppress the root hair cell development mutant lrx1.Journal of experimental botany · 2019Article
- So Many Roads: the Multifaceted Regulation of Autophagy Induction.Molecular and cellular biology · 2018Review
- SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation.Molecular cell · 2018Article
- Septins are involved at the early stages of macroautophagy inJournal of cell science · 2018Article
- A balancing act: mTOR integrates nutrient signals to regulate redox-dependent growth and survival through SOD1.Molecular & cellular oncology · 2018Article
- Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast.PloS one · 2018Article
- Multiple amino acid sensing inputs to mTORC1.Cell research · 2016Review
- Histone H3 and TORC1 prevent organelle dysfunction and cell death by promoting nuclear retention of HMGB proteins.Epigenetics & chromatin · 2016Article
- Candida glabrata: new tools and technologies-expanding the toolkit.FEMS yeast research · 2015Review
- Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.Oncotarget · 2015Article
- Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase.Acta neuropathologica communications · 2015Article
- Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae.Biological research · 2015Article
- Both the autophagy and proteasomal pathways facilitate the Ubp3p-dependent depletion of a subset of translation and RNA turnover factors during nitrogen starvation in Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2015Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The target of rapamycin protein (TOR) is a highly conserved ataxia telangiectasia-related protein kinase essential for cell growth. Emerging evidence indicates that TOR signaling is highly complex and is involved in a variety of cellular processes. To understand its general functions, we took a chemical genomics approach to explore the genetic interaction between TOR and other yeast genes on a genomic scale. In this study, the rapamycin sensitivity of individual deletion mutants generated by the Saccharomyces Genome Deletion Project was systematically measured. Our results provide a global view of the rapamycin-sensitive functions of TOR. In contrast to conventional genetic analysis, this approach offers a simple and thorough analysis of genetic interaction on a genomic scale and measures genetic interaction at different possible levels. It can be used to study the functions of other drug targets and to identify novel protein components of a conserved core biological process such as DNA damage checkpoint/repair that is interfered with by a cell-permeable chemical compound.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.