ArticleAmerican journal of human genetics2000
The extent of linkage disequilibrium in four populations with distinct demographic histories.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.American journal of human genetics · 2017Article
- Combined effects of multiple linked loci on pairwise sibling tests.International journal of legal medicine · 2017Article
- Colocalization of GWAS and eQTL Signals Detects Target Genes.American journal of human genetics · 2016Article
- Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome.Scientific reports · 2016Article
- Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases.European journal of human genetics : EJHG · 2016Article
- Genetic diversity, linkage disequilibrium, population structure and construction of a core collection of Prunus avium L. landraces and bred cultivars.BMC plant biology · 2016Article
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- Beyond GWASs: illuminating the dark road from association to function.American journal of human genetics · 2013Review
- Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation.PLoS computational biology · 2012Article
- Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity.European journal of human genetics : EJHG · 2011Article
- Genomic Diversity in Pig (Sus scrofa) and its Comparison with Human and other Livestock.Current genomics · 2011Article
- Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.Genetic epidemiology · 2010Article
- Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island.European journal of human genetics : EJHG · 2010Article
- Multiple sclerosis associates with LILRA3 deletion in Spanish patients.Genes and immunity · 2009Article
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- Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group.The pharmacogenomics journal · 2009Review
- Haplotype block partitioning as a tool for dimensionality reduction in SNP association studies.BMC genomics · 2008Article
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20 authors.
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Abstract
The design and feasibility of whole-genome-association studies are critically dependent on the extent of linkage disequilibrium (LD) between markers. Although there has been extensive theoretical discussion of this, few empirical data exist. The authors have determined the extent of LD among 38 biallelic markers with minor allele frequencies >.1, since these are most comparable to the common disease-susceptibility polymorphisms that association studies aim to detect. The markers come from three chromosomal regions-1,335 kb on chromosome 13q12-13, 380 kb on chromosome 19q13.2, and 120 kb on chromosome 22q13.3-which have been extensively mapped. These markers were examined in approximately 1,600 individuals from four populations, all of European origin but with different demographic histories; Afrikaners, Ashkenazim, Finns, and East Anglian British. There are few differences, either in allele frequencies or in LD, among the populations studied. A similar inverse relationship was found between LD and distance in each genomic region and in each population. Mean D' is.68 for marker pairs <5 kb apart and is.24 for pairs separated by 10-20 kb, and the level of LD is not different from that seen in unlinked marker pairs separated by >500 kb. However, only 50% of marker pairs at distances <5 kb display sufficient LD (delta>.3) to be useful in association studies. Results of the present study, if representative of the whole genome, suggest that a whole-genome scan searching for common disease-susceptibility alleles would require markers spaced < or = 5 kb apart.
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