ArticleAmerican journal of human genetics2000
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Article
- Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?Life (Basel, Switzerland) · 2022Review
- Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study.Journal of clinical medicine · 2018Article
- Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease.International journal of genomics · 2018Article
- Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.BMC genetics · 2017Article
- Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease.Scientific reports · 2017Article
- Distinctive Clinical Profile of Blacks Versus Whites Presenting With Sudden Cardiac Arrest.Circulation · 2015Article
- Integrative genomics in cardiovascular medicine.Cardiovascular research · 2013Review
- VAMP-8 gene variant is associated with increased risk of early myocardial infarction.Archives of medical science : AMS · 2011Article
- Genomic approaches to coronary artery disease.The Indian journal of medical research · 2010Review
- Genome-wide association study of coronary artery disease.International journal of hypertension · 2010Article
- Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease.European journal of human genetics : EJHG · 2010Article
- Genomics of heart failure.Heart failure clinics · 2010Review
- Genetics and cardiovascular disease: Design and development of a DNA biobank.Experimental and clinical cardiology · 2009Article
- Athsq1 is an atherosclerosis modifier locus with dramatic effects on lesion area and prominent accumulation of versican.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Genetic variation and atherosclerosis.Current genomics · 2008Article
- Molecular genetics of myocardial infarction.Genomic medicine · 2008Article
- Molecular signatures of cardiovascular disease risk: potential for test development and clinical application.Molecular diagnosis & therapy · 2008Review
- Genes, diet and public health.Genes & nutrition · 2007Article
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Authors and funding
17 authors at 8 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Coronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. To assess the genetic background of CHD, we performed a genomewide linkage scan in two study samples from the genetically isolated population of Finland. An initial study sample consisted of family material from the northeastern part of Finland, settled by a small number of founders approximately 300 years ago. A second study sample originated from the southwestern region of Finland, settled approximately 2,000 years ago. Families were ascertained through probands exhibiting premature CHD, defined as >50% stenosis of at least two coronary arteries at a young age, as verified by coronary angiography. Both study samples and the pooled data set provided evidence for linkage in two chromosomal regions. A region on chromosome 2q21.1-22 yielded two-point LOD scores of 3.2, 1.9, and 3.7, in the affected sib-pair (ASP) analyses of the northeastern, southwestern, and pooled study samples. The corresponding multipoint maximum-likelihood scores (MLSs) for these three study samples were 2.4, 1.3, and 3.0. In addition, a region on chromosome Xq23-26 resulted in two-point LOD scores of 1.9, 3.5, and 2.9 and in multipoint MLSs of 3.4, 3.1, and 2.5, respectively. In conclusion, this study identifies two loci likely to contribute to premature CHD: one on chromosome 2q21.1-22 and another on chromosome Xq23-26.
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