ArticleGut2000
Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 106 citations in OpenAlex.
- Influence of proton pump inhibitor use in gastrointestinal polyps.The Kaohsiung journal of medical sciences · 2010Trial
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- Development of an exosome-related and immune microenvironment prognostic signature in colon adenocarcinoma.Frontiers in genetics · 2022Article
- Progress in elucidating the relationship betweenWorld journal of gastroenterology · 2021Article
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- Cholecystokinin type 2 receptor in colorectal cancer: diagnostic and therapeutic target.Journal of cancer research and clinical oncology · 2020Article
- Effect of Proton Pump Inhibitors on Colorectal Cancer.International journal of molecular sciences · 2020Article
- Association ofWorld journal of gastrointestinal oncology · 2020Article
- Article
- Clinical significance of serum markers reflecting gastric function andJournal of Cancer · 2019Article
- Article
- Article
- Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma.Oncology letters · 2016Article
- Progastrin a new pro-angiogenic factor in colorectal cancer.Oncogene · 2015Article
- Republished: tracing PAKs from GI inflammation to cancer.Postgraduate medical journal · 2014Article
- Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.Physiological reports · 2014Article
- MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Is colonoscopic screening necessary for patients with gastric adenoma or cancer?Digestive diseases and sciences · 2013Article
- Role of gastrin-peptides in Barrett's and colorectal carcinogenesis.World journal of gastroenterology · 2012Review
- Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells.Current colorectal cancer reports · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsGastrin and the cholecystokinin type B/gastrin receptor (CCKBR) have been shown to be expressed in colorectal adenocarcinoma. Both exogenous and autocrine gastrin have been demonstrated to stimulate growth of colorectal cancer but it is not known if gastrin affects the growth of colonic polyps. The purpose of this study was to determine if gastrin and CCKBR are expressed in human colonic polyps and to determine at which stage of progression this occurs.
methodsA range of human colonic polyps was assessed for gastrin and CCKBR gene and protein expression.
resultsNormal colonic mucosa did not express gastrin or CCKBR. Gastrin and CCKBR reverse transcription-polymerase chain reaction products were detected and verified by specific hybridisation with an oligo probe on Southern blots. Gastrin and CCKBR were expressed in 78% and 81% of polyps, respectively. Both genes were coexpressed in 97% of cases. Immunohistochemistry identified progastrin in 91%, glycine extended gastrin 17 in 80%, and amidated gastrin 17 in only 47% of polyps. CCKBR was present in 96% of polyps. Expression of gastrin and CCKBR was seen in all histological types and sizes of polyps.
conclusionsThis study is the first to show widespread expression of both gastrin and its receptor in colorectal polyps. Their activation occurs early in the adenoma-carcinoma sequence. Gastrin may promote progression through the adenoma-carcinoma sequence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.