ArticleGenome research2000
Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 111 citations in OpenAlex.
- Evolutionary hotspots of structural variation drive inter-individual differences in the expression of fusion transcripts in the human brain.Nucleic acids research · 2025Article
- Regulatory Mechanisms and Functional Roles of Readthrough Transcripts in Tumorigenesis.International journal of molecular sciences · 2025Review
- A Protocol for the Detection of Fusion Transcripts Using RNA-Sequencing Data.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Functional dissection and assembly of a small, newly evolved, W chromosome-specific genomic region of the African clawed frog Xenopus laevis.PLoS genetics · 2023Article
- Gene fusion as an important mechanism to generate new genes in the genus Oryza.Genome biology · 2022Article
- TMEM189 negatively regulates the stability of ULK1 protein and cell autophagy.Cell death & disease · 2022Article
- Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1'-Desaturase PEDS1 for Human Plasmalogen Biosynthesis.Frontiers in cell and developmental biology · 2022Review
- Single-Cell Transcriptomics Reveals Splicing Features of Adult Neural Stem Cells in the Subventricular Zone.Frontiers in cell and developmental biology · 2022Article
- Light-Triggered Carotenogenesis inMicroorganisms · 2021Review
- A Novel Mutation of theInternational journal of molecular sciences · 2020Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fusion Transcripts of Adjacent Genes: New Insights into the World of Human Complex Transcripts in Cancer.International journal of molecular sciences · 2019Review
- Gene Fusions Derived by Transcriptional Readthrough are Driven by Segmental Duplication in Human.Genome biology and evolution · 2019Article
- Search for potential reading frameshifts in cds from Arabidopsis thaliana and other genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway.Biochemical and biophysical research communications · 2017Article
- Isolation and functional analysis of fatty acid desaturase genes from peanut (Arachis hypogaea L.).PloS one · 2017Article
- Rad51C-ATXN7 fusion gene expression in colorectal tumors.Molecular cancer · 2016Article
- Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma.Oncotarget · 2016Article
- The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa.PLoS genetics · 2016Article
- Transcription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis?Omics : a journal of integrative biology · 2014Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the RAD6-mediated error-free DNA repair pathway. In mammalian cells, UEV proteins can modulate c-FOS transcription and the G2-M transition of the cell cycle. Here we show that the UEV genes from phylogenetically distant organisms present a remarkable conservation in their exon-intron structure. We also show that the human UEV1 gene is fused with the previously unknown gene Kua. In Caenorhabditis elegans and Drosophila melanogaster, Kua and UEV are in separated loci, and are expressed as independent transcripts and proteins. In humans, Kua and UEV1 are adjacent genes, expressed either as separate transcripts encoding independent Kua and UEV1 proteins, or as a hybrid Kua-UEV transcript, encoding a two-domain protein. Kua proteins represent a novel class of conserved proteins with juxtamembrane histidine-rich motifs. Experiments with epitope-tagged proteins show that UEV1A is a nuclear protein, whereas both Kua and Kua-UEV localize to cytoplasmic structures, indicating that the Kua domain determines the cytoplasmic localization of Kua-UEV. Therefore, the addition of a Kua domain to UEV in the fused Kua-UEV protein confers new biological properties to this regulator of variant polyubiquitination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.