ArticleMolecular and cellular biology2000
Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 81 citations in OpenAlex.
- The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts.Nucleic acids research · 2023Article
- An analysis of the role of HnRNP C dysregulation in cancers.Biomarker research · 2022Review
- Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus.FEBS open bio · 2021Review
- Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins.Frontiers in immunology · 2021Review
- Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells.International journal of molecular sciences · 2019Review
- NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.Nature communications · 2018Article
- A three-state model for the regulation of telomerase by TERRA and hnRNPA1.Nucleic acids research · 2013Article
- hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang.OncoTargets and therapy · 2013Article
- Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Expression profile of telomere-associated genes in multiple myeloma.Journal of cellular and molecular medicine · 2012Article
- The regulation of AβPP expression by RNA-binding proteins.Ageing research reviews · 2012Review
- TERRA transcripts are bound by a complex array of RNA-binding proteins.Nature communications · 2010Article
- Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS.Molecular & cellular proteomics : MCP · 2010Article
- Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.The Journal of biological chemistry · 2009Article
- Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair.International journal of radiation biology · 2009Review
- Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.Molecular cell · 2007Article
- The biogenesis and regulation of telomerase holoenzymes.Nature reviews. Molecular cell biology · 2006Review
- In vivo identification of ribonucleoprotein-RNA interactions.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Telomerase confers resistance to caspase-mediated apoptosis.Clinical interventions in aging · 2006Article
- An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization.Molecular biology of the cell · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Here we demonstrate that heterogeneous nuclear ribonucleoproteins (hnRNPs) C1 and C2 can associate directly with the integral RNA component of mammalian telomerase. The binding site for hnRNPs C1 and C2 maps to a 6-base uridylate tract located directly 5' to the template region in the human telomerase RNA (TR) and a 4-base uridylate tract directly 3' to the template in the mouse TR. Telomerase activity is precipitated with antibodies specific to hnRNPs C1 and C2 from cells expressing wild-type human TR but not a variant of the human TR lacking the hnRNPs C1 and C2 binding site, indicating that hnRNPs C1 and C2 require the 6-base uridylate tract within the human TR to associate with the telomerase holoenzyme. In addition, we demonstrate that binding of hnRNPs C1 and C2 to telomerase correlates with the ability of telomerase to access the telomere. Although correlative, these data do suggest that the binding of hnRNPs C1 and C2 to telomerase may be important for the ability of telomerase to function on telomeres. The C proteins of the hnRNP particle are also capable of colocalizing with telomere binding proteins, suggesting that the C proteins may associate with telomeres in vivo. Therefore, human telomerase is capable of associating with core members of the hnRNP family of RNA binding proteins through a direct and sequence-specific interaction with the human TR. This is also the first account describing the precise mapping of a sequence in the human TR that is required to associate with an auxiliary component of the human telomerase holoenzyme.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.