ArticleMolecular and cellular biology2000
Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2.Oncogenesis · 2023Article
- Antiepileptogenic Effect of Retinoic Acid.Current neuropharmacology · 2021Article
- Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases.Journal of experimental neuroscience · 2015Review
- Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.The Journal of biological chemistry · 2014Article
- A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.Nucleic acids research · 2013Article
- Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.PloS one · 2013Article
- Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.Molecular endocrinology (Baltimore, Md.) · 2012Review
- Absence of NR2E1 mutations in patients with aniridia.Molecular vision · 2012Article
- Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia.The Journal of biological chemistry · 2011Article
- Orphan nuclear receptors as targets for drug development.Pharmaceutical research · 2010Review
- Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Article
- Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malformations in the eye can be caused by either an excess or deficiency of retinoids. An early target gene of the retinoid metabolite, retinoic acid (RA), is that encoding one of its own receptors, the retinoic acid receptor beta (RARbeta). To better understand the mechanisms underlying this autologous regulation, we characterized the chick RARbeta2 promoter. The region surrounding the transcription start site of the avian RARbeta2 promoter is over 90% conserved with the corresponding region in mammals and confers strong RA-dependent transactivation in primary cultured embryonic retina cells. This response is selective for RAR but not retinoid X receptor-specific agonists, demonstrating a principal role for RAR(s) in retina cells. Retina cells exhibit a far higher sensitivity to RA than do fibroblasts or osteoblasts, a property we found likely due to expression of the orphan nuclear receptor TLX. Ectopic expression of TLX in fibroblasts resulted in increased sensitivity to RA induction, an effect that is conserved between chick and mammals. We have identified a cis element, the silencing element relieved by TLX (SET), within the RARbeta2 promoter region which confers TLX- and RA-dependent transactivation. These results indicate an important role for TLX in autologous regulation of the RARbeta gene in the eye.
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