ArticleThe American journal of pathology2000
Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Irinotecan therapy and molecular targets in colorectal cancer: a systemic review.World journal of gastroenterology · 2009Pooled it
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- The Role of CXC Chemokines in Cancer Progression.Cancers · 2022Review
- Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay.Diagnostics (Basel, Switzerland) · 2022Article
- Endosialin/CD248 may be a potential therapeutic target to prevent the invasion and metastasis in osteosarcoma.Oncology letters · 2022Article
- CXCL8 Signaling in the Tumor Microenvironment.Advances in experimental medicine and biology · 2021Review
- Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma.Oncotarget · 2020Article
- Role ofInternational journal of molecular sciences · 2020Article
- Targeting claudin-4 enhances chemosensitivity in breast cancer.Cancer science · 2020Article
- Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.Oncotarget · 2020Article
- Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.Cancer medicine · 2019Article
- Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.Oncotarget · 2018Article
- Expression of long-chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study.Oncology letters · 2018Article
- Pancreatic DCLK1Cancer letters · 2018Article
- Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis.World journal of gastroenterology · 2017Article
- Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer.Oncotarget · 2016Review
- Field cancerisation in colorectal cancer: a new frontier or pastures past?World journal of gastroenterology · 2015Review
- Elevated proinflammatory cytokine IL-17A in the adjacent tissues along the adenoma-carcinoma sequence.Pathology oncology research : POR · 2015Article
- The Chemokine CXCL8 in Carcinogenesis and Drug Response.ISRN oncology · 2013Review
- Diabetes-associated angiotensin activation enhances liver metastasis of colon cancer.Clinical & experimental metastasis · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
We determined whether hyperplastic mucosa adjacent to colon cancer contributes to neoplastic angiogenesis. Surgical specimens of human colon cancer (40 Dukes' stage B and 34 Dukes' stage C) were analyzed by immunohistochemistry for expression of proliferative and angiogenic molecules. The mucosa adjacent to Dukes' stage C tumors (but not Dukes' stage B tumors) had a higher Ki-67 labeling index and a higher expression of epidermal growth factor receptor and transforming growth factor-alpha than distant mucosa. The expression levels of vascular endothelial growth factor, basic fibroblast growth factor, interleukin-8, and the vascular density in the adjacent mucosa were similar to those in the tumor lesions and significantly higher than those in the distant mucosa. The expression of interferon-beta inversely correlated with the level of pro-angiogenic molecules and the vascular density. The injection of metastatic human colon cancer cells and murine colon cancer cells into the cecal wall of mice induced hyperplastic changes in the adjacent mucosa which expressed higher levels of epidermal growth factor receptor, basic fibroblast growth factor, and vascular endothelial growth factor, and lower levels of interferon-beta than did the control mucosa, which directly correlated with the degree of hyperplasia. These data suggest that metastatic human colon cancer cells can induce hyperplasia in the adjacent mucosa, which in turn produces angiogenic molecules that contribute to neoplastic angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.