ArticleThe American journal of pathology2000
Genomic alterations in well-differentiated gastrointestinal and bronchial neuroendocrine tumors (carcinoids): marked differences indicating diversity in molecular pathogenesis.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 106 citations in OpenAlex.
- Neuroendocrine Tumors: Genomics and Molecular Biomarkers with a Focus on Metastatic Disease.Cancers · 2023Review
- Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors.Genes, chromosomes & cancer · 2020Article
- Article
- The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes.Reviews in endocrine & metabolic disorders · 2020Review
- Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Molecular strategies in the management of bronchopulmonary and thymic neuroendocrine neoplasms.Journal of thoracic disease · 2017Review
- Neuroendocrine tumors of the thymus and mediastinum.Journal of thoracic disease · 2017Review
- PI3K/AKT/mTOR pathway in pulmonary carcinoid tumours.Oncology letters · 2017Article
- Rare airway tumors: an update on current diagnostic and management strategies.Journal of thoracic disease · 2016Article
- Genomic landscape of pancreatic neuroendocrine tumors.World journal of gastroenterology · 2014Article
- Second primary malignancies in patients with neuroendocrine tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
- Gene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumors.BMC genomics · 2014Article
- New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines.PloS one · 2014Article
- Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization.BMC cancer · 2013Article
- Histopathology of gastrointestinal neuroendocrine neoplasms.Frontiers in oncology · 2013Article
- Typical bronchial carcinoid metastasizing to the brain: a case presentation.Case reports in oncology · 2011Article
- Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome.The American journal of pathology · 2011Article
- Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential.Experimental & molecular medicine · 2009Article
- Molecular profiles of gastroenteropancreatic endocrine tumors.Virchows Archiv : an international journal of pathology · 2007Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroendocrine tumors (carcinoids) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. Genetic changes underlying their tumorigenesis are primarily unknown. We used comparative genomic hybridization to screen 32 well-differentiated neuroendocrine tumors (21 gastrointestinal and 11 bronchial) and three associated metastases for genomic alterations. There were striking differences of genomic imbalances between the two subgroups of neuroendocrine tumors. Losses of chromosome 18q and 18p were shown in eight (38%) and seven (33%), respectively, out of 21 gastrointestinal tumors and in none of the 11 bronchial tumors. Conversely, deletions of 11q occurred in four of 11 (36%) bronchial tumors but only in one gastrointestinal tumor. These comparative genomic hybridization findings were confirmed by interphase cytogenetics. Our data indicate that neuroendocrine tumors of the two subgroups develop via different molecular pathways. Inactivation of one or several tumor suppressor genes on chromosome 18 may be important for the biological behavior of gastrointestinal tumors, whereas gene inactivation on 11q seems to be associated with tumor development of the bronchi.
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