Evidence map›Paper›PMID 11073508›Full record

SynthesisBMJ (Clinical research ed.)2000

Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis.

S Derry, Y K Loke

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00594867 (Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.), which is not on this map. Cited by 172 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 19 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00594867 phase4completednot on this mapstarted 2006, after this paper: background citation

Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2006 to 2007Enrolled94ConditionsHealthyArmsAcetaminophen - 4 grams per day + Placebo, Aspirin - 325 mg per day + Placebo, Acetaminophen 4 gram per day + Aspirin 325 mg per day
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 19 syntheses or guidelines pooled it, 677 citations in OpenAlex.

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  6. Aspirin for in vitro fertilisation.The Cochrane database of systematic reviews · 2016
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

S DerryDepartment of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE.
Y K Loke
University of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage.

designMeta-analysis of 24 randomised controlled trials (almost 66 000 participants).

interventionAspirin compared with placebo or no treatment, for a minimum of one year.

main outcome measuresIncidence of gastrointestinal haemorrhage.

resultsGastrointestinal haemorrhage occurred in 2.47% of patients taking aspirin compared with 1.42% taking placebo (odds ratio 1.68; 95% confidence interval 1.51 to 1.88); the number needed to harm was 106 (82 to 140) based on an average of 28 months' therapy. At doses below 163 mg/day, gastrointestinal haemorrhage occurred in 2.30% of patients taking aspirin compared with 1.45% taking placebo (1.59; 1.40 to 1.81). Meta-regression showed no relation between gastrointestinal haemorrhage and dose. For modified release formulations of aspirin the odds ratio was 1.93 (1.15 to 3.23).

conclusionsLong term therapy with aspirin is associated with a significant increase in the incidence of gastrointestinal haemorrhage. No evidence exists that reducing the dose or using modified release formulations would reduce the incidence of gastrointestinal haemorrhage.

Indexed as

AspirinCyclooxygenase InhibitorsDose-Response Relationship, DrugFibrinolytic AgentsGastrointestinal HemorrhageHumansLong-Term CareOdds RatioRandomized Controlled Trials as TopicRisk FactorsAspirinCyclooxygenase InhibitorsFibrinolytic Agents

Identifiers

PMID11073508
PMCPMC27521
OpenAlexW2071335057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.