ArticleNucleic acids research2000
DNA-triplex stabilizing properties of 8-aminoguanine.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Recognition of non-standard base pairs by triplex-forming oligonucleotides containing an expanded genetic alphabet.Nature communications · 2026Article
- Recognition of Non-standard Base Pairs by Triplex-Forming Oligonucleotides Containing an Expanded Genetic Alphabet.Research square · 2026Article
- Synthesis and surface characterization of new triplex polymer of Ag(I) and mixture nucleosides: cytidine and 8-bromoguanosine.Heliyon · 2019Article
- Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.Nucleic acids research · 2017Article
- New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.Nucleic acids research · 2015Review
- Dynamical treatment of charge transfer through duplex nucleic acids containing modified adenines.ACS nano · 2013Article
- Synthesis and structural characterization of stable branched DNA g-quadruplexes using the trebler phosphoramidite.ChemistryOpen · 2012Article
- Structural properties of g,t-parallel duplexes.Journal of nucleic acids · 2010Article
- Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformers.Biophysical journal · 2007Article
- Recombination R-triplex: H-bonds contribution to stability as revealed with minor base substitutions for adenine.Nucleic acids research · 2006Article
- Monitoring denaturation behaviour and comparative stability of DNA triple helices using oligonucleotide-gold nanoparticle conjugates.Nucleic acids research · 2004Article
- Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines.Nucleic acids research · 2002Article
- The effect of amino groups on the stability of DNA duplexes and triplexes based on purines derived from inosine.Nucleic acids research · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calculations, and demonstrated by melting experiments. NMR experiments confirm the triplex-stabilizing properties of 8-aminoguanine and demonstrate that few changes are found in the structure of the triplex due to the presence of this modified base.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.