ArticleNucleic acids research2000
The two Saccharomyces cerevisiae SUA7 (TFIIB) transcripts differ at the 3'-end and respond differently to stress.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Promoter-Terminator Gene Loops Affect Alternative 3'-End Processing in Yeast.The Journal of biological chemistry · 2016Article
- Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- UV damage regulates alternative polyadenylation of the RPB2 gene in yeast.Nucleic acids research · 2013Article
- Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Noncanonical transcript forms in yeast and their regulation during environmental stress.RNA (New York, N.Y.) · 2010Article
- Alternative 3' pre-mRNA processing in Saccharomyces cerevisiae is modulated by Nab4/Hrp1 in vivo.PLoS biology · 2007Article
- Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization.Molecular and cellular biology · 2003Article
- Probabilistic prediction of Saccharomyces cerevisiae mRNA 3'-processing sites.Nucleic acids research · 2002Article
- Mpe1, a zinc knuckle protein, is an essential component of yeast cleavage and polyadenylation factor required for the cleavage and polyadenylation of mRNA.Molecular and cellular biology · 2001Article
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3 authors.
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Abstract
Despite much information as to the structure and function of the general transcription factors, little is known about the regulation of their expression. Transcription of the Saccharomyces cerevisiae SUA7 (TFIIB) gene results in the formation of two discrete transcripts. It was originally reported that the two transcripts were derived from two promoters separated by approximately 80 bp. We have found that the two transcripts are instead derived from a common promoter and differ at the 3'-end by approximately 115 bp. The longer of the two transcripts has an unusually long 3'-untranslated region. We have analyzed the levels of these transcripts under different cell growth conditions and find that the relative amounts of the two transcripts vary. Approximately equal amounts of each transcript are observed during exponential growth, but stresses and growth limiting conditions lead to a decrease in the relative amount of the larger transcript. These results suggest that the expression of the SUA7 gene may be controlled by regulation of 3'-end formation or mRNA stability. One of the general transcription factors, then, may be subject to regulation by a general response of the mRNA processing machinery.
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