ArticleMolecular biology of the cell2000
Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation.FEBS open bio · 2018Article
- A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.Cell reports · 2016Article
- Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.Cell & bioscience · 2015Article
- Hypoxia-inducible factor as an angiogenic master switch.Frontiers in pediatrics · 2015Review
- Targeting translation initiation in breast cancer.Translation (Austin, Tex.) · 2014Review
- Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.Oncogene · 2013Article
- Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.RNA (New York, N.Y.) · 2012Article
- Article
- An oncogenic role of eIF3e/INT6 in human breast cancer.Oncogene · 2010Article
- Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.Molecular cell · 2009Article
- Article
- Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome.Plant signaling & behavior · 2008Article
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- The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.Neuron · 2007Article
- Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.Oncogene · 2007Article
- Reconstitution reveals the functional core of mammalian eIF3.The EMBO journal · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Mammalian INT6 protein has been considered to be a subunit of the eukaryotic translation initiation factor, eIF3. The Int6 locus is also known as a common integration site of mouse mammary tumor virus (MMTV). However, the function of Int6 in translation initiation and the mechanism of Int6-mediated tumor induction are yet to be explored. In this study, the fission yeast, Schizosaccharomyces pombe, int6(+), which is 43% identical to the mammalian counterpart, was deleted. Despite the evidence that the majority of Int6 protein was associated with 40S particles in this organism, strains lacking int6(+) (Deltaint6) were viable and showed only moderate inhibition in the rate of in vivo global protein synthesis. Polysome profile analysis showed no apparent defects in translation initiation. Deltaint6 exhibited a hypersensitivity to caffeine, which could be suppressed by the addition of sorbitol to the growth medium. This and other phenotypes would imply that int6(+) is required for the integrity of cell membrane. In meiosis, Deltaint6 produced incomplete tetrads frequently. High dosage expression of a truncated mutant of int6(+) conferred a hypersensitivity to caffeine, but did not cause the defect in meiosis. A possible link between the function of int6(+) and the Deltaint6-phenotypes is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.