ArticleMolecular biology of the cell2000
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Article
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- Functional characterization of a novel CSF1R mutation causing hereditary diffuse leukoencephalopathy with spheroids.Molecular genetics & genomic medicine · 2019Article
- Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition.Leukemia · 2017Article
- Gene Expression Profiling of Pulmonary Artery in a Rabbit Model of Pulmonary Thromboembolism.PloS one · 2016Article
- The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host-pathogen interactions.Cellular microbiology · 2015Article
- Src signaling pathways in prostate cancer.Cancer metastasis reviews · 2014Review
- Perlecan is required for FGF-2 signaling in the neural stem cell niche.Stem cell research · 2014Article
- Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways.PLoS computational biology · 2013Article
- A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Expression of cyclin D2, P53, Rb and ATM cell cycle genes in brain tumors.Medical oncology (Northwood, London, England) · 2011Article
- Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.PloS one · 2011Article
- M-CSF potently augments RANKL-induced resorption activation in mature human osteoclasts.PloS one · 2011Article
- Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways.Cellular signalling · 2008Article
- Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.American journal of physiology. Heart and circulatory physiology · 2008Article
- Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes.Cancer science · 2007Article
- The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.Oncogene · 2007Review
- ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targets.Molecular biology of the cell · 2007Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Colony-stimulating factor-1 (CSF-1) induces expression of immediate early gene, such as c-myc and c-fos and delayed early genes such as D-type cyclins (D1 and D2), whose products play essential roles in the G1 to S phase transition of the cell cycle. Little is known, however, about the cytoplasmic signal transduction pathways that connect the surface CSF-1 receptor to these genes in the nucleus. We have investigated the signaling mechanism of CSF-1-induced D2 expression. Analyses of CSF-1 receptor autophosphorylation mutants show that, although certain individual mutation has a partial inhibitory effect, only multiple combined mutations completely block induction of D2 in response to CSF-1. We report that at least three parallel pathways, the Src pathway, the MAPK/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, and the c-myc pathway, are involved. Induction of D2 is partially inhibited in Src(-/-) bone marrow-derived macrophages and by Src inhibitor PP1 and is enhanced in v-Src-overexpressing cells. Activation of myc's transactivating activity selectively induces D2 but not D1. Blockade of c-myc expression partially blocks CSF-1-induced D2 expression. Complete inhibition of the MEK/ERK pathway causes 50% decrease of D2 expression. Finally, simultaneous inhibition of Src, MEK activation, and c-myc expression additively blocks CSF-1-induced D2 expression. This study indicates that multiple signaling pathways are involved in full induction of a single gene, and this finding may also apply broadly to other growth factor-inducible genes.
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