ArticleJournal of virology2000
Human immunodeficiency virus Env-independent infection of human CD4(-) cells.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- HIV-Tocky system to visualize proviral expression dynamics.Communications biology · 2024Article
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- Dendritic Cells, the Double Agent in the War Against HIV-1.Frontiers in immunology · 2019Review
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- Involvement of non-structural proteins (NS) in influenza A infection and viral tropism.Biochemical and biophysical research communications · 2012Article
- Plausibility of HIV-1 Infection of Oral Mucosal Epithelial Cells.Advances in dental research · 2011Review
- Article
- Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection.Journal of virological methods · 2009Article
- Stone age diseases and modern AIDS.Virology journal · 2008Article
- Oral keratinocytes support non-replicative infection and transfer of harbored HIV-1 to permissive cells.Retrovirology · 2008Article
- Involvement of claudin-7 in HIV infection of CD4(-) cells.Retrovirology · 2005Article
- Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytes.Journal of virology · 2004Article
- Article
- The Trojan exosome hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Regulation of the expression of the prostate-specific antigen by claudin-7.The Journal of membrane biology · 2003Article
- Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Feline immunodeficiency virus xenoinfection: the role of chemokine receptors and envelope diversity.Journal of virology · 2002Article
- Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
CD4(-) epithelial cells covering mucosal surfaces serve as the primary barrier to prevent human immunodeficiency virus type 1 (HIV-1) infection. We used HIV-1 vectors carrying the enhanced green fluorescent protein gene as a reporter gene to demonstrate that HIV-1 can infect some CD4(-) human epithelial cell lines with low but significant efficiencies. Importantly, HIV-1 infection of these cell lines is independent of HIV-1 envelope proteins. The Env-independent infection of CD4(-) cells by HIV-1 suggests an alternative pathway for HIV-1 transmission. Even on virions bearing Env, a neutralizing antibody directed against gp120 is incapable of neutralizing the infection of these cells, thus raising potential implications for HIV-1 vaccine development.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.