ArticleJournal of virology2000
Hepatitis A virus-specific immunoglobulin A mediates infection of hepatocytes with hepatitis A virus via the asialoglycoprotein receptor.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 106 citations in OpenAlex.
- Whole-Genome Sequencing-Based Confirmatory Methods on RT-qPCR Results for the Detection of Foodborne Viruses in Frozen Berries.Food and environmental virology · 2024Article
- Hepatitis A virus infection.Nature reviews. Disease primers · 2023Review
- Pathogenicity and virulence of hepatitis A virus.Virulence · 2021Review
- Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice.Seminars in liver disease · 2020Review
- Adaptive Immune Responses in Hepatitis A Virus and Hepatitis E Virus Infections.Cold Spring Harbor perspectives in medicine · 2019Review
- Hepatitis A Virus Capsid Structure.Cold Spring Harbor perspectives in medicine · 2019Review
- A Novel Marsupial Hepatitis A Virus Corroborates Complex Evolutionary Patterns Shaping the Genus Hepatovirus.Journal of virology · 2018Article
- Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus.Frontiers in microbiology · 2018Review
- Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor.Frontiers in genetics · 2018Article
- Article
- Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules.Chemical science · 2016Article
- A novel hepatovirus identified in wild woodchuck Marmota himalayana.Scientific reports · 2016Article
- Specific IgA Enhances the Transcytosis and Excretion of Hepatitis A Virus.Scientific reports · 2016Article
- Evolutionary origins of hepatitis A virus in small mammals.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes.Chemical science · 2015Article
- Hepatitis A virus and the origins of picornaviruses.Nature · 2015Article
- Molecular biology and inhibitors of hepatitis A virus.Medicinal research reviews · 2014Review
- A 'clicked' tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level.Scientific reports · 2014Article
- Hepatitis A: Natural history, immunopathogenesis, and outcome.Clinical liver disease · 2013Review
- Liver immunology.Comprehensive Physiology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the hepatotropism of hepatitis A virus (HAV) and the relapsing courses of HAV infections are unknown. In this report, we show for a mouse hepatocyte model that HAV-specific immunoglobulin A (IgA) mediates infection of hepatocytes with HAV via the asialoglycoprotein receptor, which binds and internalizes IgA molecules. Proof of HAV infection was obtained by detection of HAV minus-strand RNA, which is indicative for virus replication, and quantification of infectious virions. We demonstrate that human hepatocytes also ingest HAV-anti-HAV IgA complexes by the same mechanism, resulting in infection of the cells, by using the HepG2 cell line and primary hepatocytes. The relevance of this surrogate receptor mechanism in HAV pathogenesis lies in the fact that HAV, IgA, and antigen-IgA complexes use the same pathway within the organism, leading from the gastrointestinal tract to the liver via blood and back to the gastrointestinal tract via bile fluid. Therefore, HAV-specific IgA antibodies produced by gastrointestinal mucosa-associated lymphoid tissue may serve as carrier and targeting molecules, enabling and supporting HAV infection of IgA receptor-positive hepatocytes and, in the case of relapsing courses, allowing reinfection of the liver in the presence of otherwise neutralizing antibodies, resulting in exacerbation of liver disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.