ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
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- The effects of estrogen depletion in female rats: differential influences on somato-motor and sensory cortices.Biogerontology · 2025Article
- Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model.Acta neuropathologica communications · 2024Article
- Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons.Neurobiology of aging · 2021Article
- Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines.Journal of neuroendocrinology · 2020Article
- Proton magnetic resonance spectroscopy reveals significant decline in the contents ofArchives of medical science : AMS · 2017Article
- Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors.Hearing research · 2017Article
- Diet-induced changes in brain structure and behavior in old gerbils.Nutrition & diabetes · 2015Article
- Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding.Frontiers in cellular neuroscience · 2015Article
- Combined two-photon imaging, electrophysiological, and anatomical investigation of the human neocortex in vitro.Neurophotonics · 2014Article
- Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons.Frontiers in aging neuroscience · 2014Review
- Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution.Neuroscience journal · 2013Article
- Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging.Neurobiology of aging · 2012Article
- Effects of electromagnetic radiation on spatial memory and synapses in rat hippocampal CA1.Neural regeneration research · 2012Article
- Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Dramatic Loss of Ube3A Expression during Aging of the Mammalian Cortex.Frontiers in aging neuroscience · 2010Article
- Synapses are lost during aging in the primate prefrontal cortex.Neuroscience · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Reduction in both presynaptic and postsynaptic structures in the aging neocortex may significantly affect functional synaptic properties in this area. To directly address this issue, we combined whole-cell patch-clamp recording of spontaneously occurring postsynaptic currents (PSCs) with morphological analysis of layer V pyramidal neurons in the parietal cortex of young adult (1- to 2-month-old) and aged (28- to 37-month-old) BN x F344 F(1) hybrid rats. Analysis of spontaneous PSCs was used to contrast functional properties of basal synaptic input with structural alterations in the dendritic tree of pyramidal neurons and density of terminals in contact with these cells. We observed significant changes in a number of morphological parameters of pyramidal neurons in aged rats. These include smaller cell body size and fewer basal dendritic branches (but not of oblique dendrites and dendritic tufts) and spines. Ultrastructural analysis also revealed a lower density of presynaptic terminals per unit length of postsynaptic membrane of labeled pyramidal neurons in the aged brain. This reduction in both presynaptic and postsynaptic elements was paralleled by a significant decrease in frequency of tetrodotoxin-insensitive miniature (action potential-independent) PSCs (mPSCs). The frequency of excitatory and inhibitory mPSCs was reduced to the same extent. In contrast, no significant change was observed in the frequency of spontaneous PSCs recorded in absence of tetrodotoxin (sPSCs), indicating an increase in action potential-dependent (frequency(sPSCs) - frequency(mPSCs)) input to pyramidal neurons in the aged group. This functional compensation may explain the lack of drastic loss of spontaneous neuronal activity in normal aging.
Indexed as
Identifiers
11069968PMC6773180W2159633226What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.