ArticleProceedings of the National Academy of Sciences of the United States of America2000
A cyclin-dependent kinase-activating kinase regulates differentiation of root initial cells in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The maize B chromosome shapes the transcriptome throughout the entire plant life cycle.Journal of experimental botany · 2025Article
- Expression, regulation and activity of a B2-type cyclin in mitotic and endoreduplicating maize endosperm.Frontiers in plant science · 2014Article
- Two Arabidopsis cyclin A3s possess G1 cyclin-like features.Plant cell reports · 2010Article
- ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis.PloS one · 2007Article
- The Arabidopsis D-type cyclin CYCD4 controls cell division in the stomatal lineage of the hypocotyl epidermis.The Plant cell · 2007Article
- The Root Apex of Arabidopsis thaliana Consists of Four Distinct Zones of Growth Activities: Meristematic Zone, Transition Zone, Fast Elongation Zone and Growth Terminating Zone.Plant signaling & behavior · 2006Article
- A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis.Plant cell reports · 2006Article
- The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication.The Plant cell · 2006Article
- Histidine kinase homologs that act as cytokinin receptors possess overlapping functions in the regulation of shoot and root growth in Arabidopsis.The Plant cell · 2004Article
- Article
- Arabidopsis D-type cyclin CYCD4;1 is a novel cyclin partner of B2-type cyclin-dependent kinase.Plant physiology · 2003Article
- Control of in vitro organogenesis by cyclin-dependent kinase activities in plants.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Altered cell cycle distribution, hyperplasia, and inhibited differentiation in Arabidopsis caused by the D-type cyclin CYCD3.The Plant cell · 2003Article
- Signaling in and out: control of cell division and differentiation in the shoot and root.The Plant cell · 2002Review
- The Cyclin-Dependent Kinase activity modulates the central carbon metabolism in maize during germination.Physiologia plantarumArticle
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cell division and differentiation continue throughout the plant life cycle without significant loss of control. However, little is known about the mechanisms that allow the continuous development of meristems. Cell division is controlled by a family of cyclin-dependent kinases (CDKs). CDK-activating kinases (CAKs) are known to phosphorylate and activate almost all CDKs and thus may have a crucial role in controlling CDK activities in each cell of the meristems. Here, we show that overexpression of sense or antisense gene for Cak1At in Arabidopsis by using the glucocorticoid-mediated transcriptional induction system resulted in a reduction of CDK activities. After 14-24 h of glucocorticoid treatment, starch granules appeared in columellar initials in the root meristem, and cortical initials were periclinally divided into cortical and endodermal cells. Accumulation of the cyclin beta-glucuronidase fusion protein ceased after 72 h of glucocorticoid treatment. Our results indicate that a change of Cak1At activity leads to differentiation of initial cells, followed by cessation of cell division. Therefore, we propose that differentiation of initial cells is controlled by Cak1At but is maintained independent of cell division.
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