ArticleProceedings of the National Academy of Sciences of the United States of America2000
The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 76 citations in OpenAlex.
- ATRX: From Chromatin Remodeling to Disease.Genesis (New York, N.Y. : 2000) · 2025Review
- Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation.Science (New York, N.Y.) · 2025Article
- Networks of pre-diagnostic circulating RNA in testicular germ cell tumour.Scientific reports · 2025Article
- Article
- Mammalian X-chromosome inactivation: proposed role in suppression of the male programme in genetic females.Journal of genetics · 2022Article
- Profile of Jennifer Marshall Graves.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Postnatal development in a marsupial model, the fat-tailed dunnart (Sminthopsis crassicaudata; Dasyuromorphia: Dasyuridae).Communications biology · 2021Article
- Miniscule differences between sex chromosomes in the giant genome of a salamander.Scientific reports · 2018Article
- Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation.Journal of genetics · 2015Review
- Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution.Genome research · 2012Article
- A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.Chromosoma · 2012Article
- No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes.PloS one · 2012Article
- Review
- Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.Genome biology · 2011Article
- ATRX has a critical and conserved role in mammalian sexual differentiation.BMC developmental biology · 2011Article
- Enhancing genome assemblies by integrating non-sequence based data.BMC proceedings · 2011Article
- Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic.Genome biology · 2010Article
- Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Article
- Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Mutations in the ATRX gene on the human X chromosome cause X-linked alpha-thalassemia and mental retardation. XY patients with deletions or mutations in this gene display varying degrees of sex reversal, implicating ATRX in the development of the human testis. To explore further the role of ATRX in mammalian sex differentiation, the homologous gene was cloned and characterized in a marsupial. Surprisingly, active homologues of ATRX were detected on the marsupial Y as well as the X chromosome. The Y-borne copy (ATRY) displays testis-specific expression. This, as well as the sex reversal of ATRX patients, suggests that ATRY is involved in testis development in marsupials and may represent an ancestral testis-determining mechanism that predated the evolution of SRY as the primary mammalian male sex-determining gene. There is no evidence for a Y-borne ATRX homologue in mouse or human, implying that this gene has been lost in eutherians and its role supplanted by the evolution of SRY from SOX3 as the dominant determiner of male differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.