ArticleThe Journal of experimental medicine2000
Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Efficacy and Risk Factors of Interferon-Gamma Release Assays among HIV-Positive Individuals.International journal of environmental research and public health · 2023Article
- Cytokine production by human B cells: role in health and autoimmune disease.Clinical and experimental immunology · 2022Review
- IFN-γ and TGF-β, Crucial Players in Immune Responses: A Tribute to Howard Young.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Review
- Inflammatory cytokine profile and T cell responses in African tick bite fever patients.Medical microbiology and immunology · 2022Article
- Assessment of cytokines, microRNA and patient related outcome measures in conversion disorder/functional neurological disorder (CD/FND): The CANDO clinical feasibility study.Brain, behavior, & immunity - health · 2021Article
- Diversified Stimuli-Induced Inflammatory Pathways Cause Skin Pigmentation.International journal of molecular sciences · 2021Review
- Double-edged effects of interferons on the regulation of cancer-immunity cycle.Oncoimmunology · 2021Review
- Roles of inflammation factors in melanogenesis (Review).Molecular medicine reports · 2020Review
- Comparative Evaluation of the Immune Responses in Cattle Mammary Tissues Naturally Infected with Bovine Parainfluenza Virus Type 3 and Bovine Alphaherpesvirus-1.Pathogens (Basel, Switzerland) · 2019Article
- Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion.Frontiers in immunology · 2018Review
- Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells.Nature communications · 2016Article
- Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.Scientific reports · 2016Article
- Review
- Antibody-independent functions of B cells: a focus on cytokines.Nature reviews. Immunology · 2015Review
- Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury.Molecular medicine (Cambridge, Mass.) · 2015Article
- Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma.Frontiers in medicine · 2015Review
- Interferon-γ induces senescence in normal human melanocytes.PloS one · 2014Article
- IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- Dual biological effects of the cytokines interleukin-10 and interferon-γ.Cancer immunology, immunotherapy : CII · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism by which immature B cells are sequestered from encountering foreign antigens present in lymph nodes or sites of inflammation, before their final maturation in the spleen, has not been elucidated. We show here that immature B cells fail to home to the lymph nodes. These cells can actively exclude themselves from antigen-enriched sites by downregulating their integrin-mediated adhesion to the extracellular matrix protein, fibronectin. This inhibition is mediated by interferon gamma secretion. Perturbation of interferon gamma activity in vivo leads to the homing of immature B cells to the lymph nodes. This is the first example of autocrine regulation of immune cell migration to sites of foreign antigen presentation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.