ArticleOncogene2000
AP-1 complex is effector of Hox-induced cellular proliferation and transformation.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans.Nature communications · 2023Article
- Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells.Cancers · 2022Review
- JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation.The Journal of biological chemistry · 2016Article
- Review
- Hox targets and cellular functions.Scientifica · 2013Article
- Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2012Article
- A role for GPx3 in activity of normal and leukemia stem cells.The Journal of experimental medicine · 2012Article
- Article
- Effect of increased HoxB4 on human megakaryocytic development.Biochemical and biophysical research communications · 2010Article
- GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.Cancer cell · 2010Article
- Article
- Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.Gastroenterology · 2008Article
- HOXB4 confers a constant rate of in vitro proliferation to transduced bone marrow cells.Oncogene · 2005Article
- High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.Genes & development · 2005Article
- Folate modulates Hox gene-controlled skeletal phenotypes.Genesis (New York, N.Y. : 2000) · 2004Article
- The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells.Oncogene · 2003Article
- Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.Molecular and cellular biology · 2003Article
- Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy.Gene therapy · 2001Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of adult tissues. There is also a growing body of evidence that links Hox proteins to regulation of cellular proliferation/transformation. However, the underlying molecular mechanisms of Hox-associated transformation and tissue growth have yet to be elucidated. Using a well established model system for studying changes in cellular proliferation induced by Hoxb4, we show that AP-1 activity is markedly increased in Hoxb4-transduced cells due to significant upregulation of Jun-B and Fra-1 protein levels. Furthermore, we also show that the specific changes in AP-1 protein expression are necessary for the proliferation effects induced by Hoxb4, and that these changes converge to increase levels of cyclin D1, a known integrator of proliferation signals. Our observations thus link Hox gene products with key elements of the cell cycle machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.