ArticleGenetics2000
New insights on homology-dependent silencing of I factor activity by transgenes containing ORF1 in Drosophila melanogaster.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- The Role of Transposable Elements in Speciation.Genes · 2018Review
- Homology-dependent silencing by an exogenous sequence in the Drosophila germline.G3 (Bethesda, Md.) · 2012Article
- Genomic instability of I elements of Drosophila melanogaster in absence of dysgenic crosses.PloS one · 2010Article
- An epigenetic role for maternally inherited piRNAs in transposon silencing.Science (New York, N.Y.) · 2008Article
- Natural epigenetic protection against the I-factor, a Drosophila LINE retrotransposon, by remnants of ancestral invasions.PloS one · 2007Article
- aubergine mutations in Drosophila melanogaster impair P cytotype determination by telomeric P elements inserted in heterochromatin.Molecular genetics and genomics : MGG · 2004Article
- Expression of the telomeric retrotransposon HeT-A in Drosophila melanogaster is correlated with cell proliferation.Development genes and evolution · 2004Article
- Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene.Genetics · 2004Article
- Gene silencing triggered by non-LTR retrotransposons in the female germline of Drosophila melanogaster.Genetics · 2003Article
- Article
- Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells.Molecular and cellular biology · 2001Article
- RNA interference is mediated by 21- and 22-nucleotide RNAs.Genes & development · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
I factors in Drosophila melanogaster are non-LTR retrotransposons that transpose at very high frequencies in the germ line of females resulting from crosses between reactive females (devoid of active I factors) and inducer males (containing active I factors). Constructs containing I factor ORF1 under the control of the hsp70 promoter repress I factor activity. This repressor effect is maternally transmitted and increases with the transgene copy number. It is irrespective of either frame integrity or transcriptional orientation of ORF1, suggesting the involvement of a homology-dependent trans-silencing mechanism. A promoterless transgene displays no repression. The effect of constructs in which ORF1 is controlled by the hsp70 promoter does not depend upon heat-shock treatments. No effect of ORF1 is detected when it is controlled by the I factor promoter. We discuss the relevance of the described regulation to the repression of I factors in I strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.