ArticleGenetics2000
A fission yeast repression element cooperates with centromere-like sequences and defines a mat silent domain boundary.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023Review
- The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin.Epigenetics & chromatin · 2022Review
- A composite DNA element that functions as a maintainer required for epigenetic inheritance of heterochromatin.Molecular cell · 2021Article
- Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.Genes & development · 2020Article
- Nucleation and spreading of a heterochromatic domain in fission yeast.Nature communications · 2016Article
- A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.PLoS genetics · 2016Article
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- Uncoupling of genomic and epigenetic signals in the maintenance and inheritance of heterochromatin domains in fission yeast.Genetics · 2012Article
- RNA interference and heterochromatin assembly.Cold Spring Harbor perspectives in biology · 2011Review
- H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.PLoS genetics · 2011Article
- Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.Genes & development · 2010Article
- Silent chromatin at the middle and ends: lessons from yeasts.The EMBO journal · 2009Review
- The impact of local genome sequence on defining heterochromatin domains.PLoS genetics · 2009Article
- Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1.Nucleic acids research · 2006Article
- The role of heterochromatin in centromere function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.Molecular and cellular biology · 2005Article
- Global effects on gene expression in fission yeast by silencing and RNA interference machineries.Molecular and cellular biology · 2005Article
- Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.Nucleic acids research · 2005Article
- Global expression changes resulting from loss of telomeric DNA in fission yeast.Genome biology · 2005Article
- A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.The EMBO journal · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
REII is a Schizosaccharomyces pombe repression element located at the centromere-proximal end of the mat silent domain. Here we show that inversion of REII enhances silencing on its centromere-proximal side while suppressing silencing on its centromere-distal side. Transplacement of REII to a position 2.5 kb from its native locus extends the region of stringent repression to the new REII site. These results suggest that REII defines a mat silent domain boundary by acting preferentially toward its centromere-distal side. To investigate cooperation between REII and a K-region sequence that shares homology with the centromeric dg dh repeats (cen2 homology), we targeted combinations of these elements to an ectopic site and monitored expression of an adjacent reporter gene. Centromeric dh-like sequences conferred low-level silencing on the adjacent reporter gene, and REII, which did not display silencing activity on its own, enhanced cen2 homology-mediated silencing. Cooperation was also apparent at the mat locus, where deletion of REII impaired repression stability. We propose that REII and the cen2 homology play different yet complementary roles in silencing establishment and inheritance at the mat locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.