ArticleGenetics2000
CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNA elements CDE I and CDE II but not CDE III. Implications for the path of the centromere dna around a cse4p variant nucleosome.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Nanoscale structural organization and stoichiometry of the budding yeast kinetochore.The Journal of cell biology · 2023Article
- Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization.Molecular cell · 2022Article
- Article
- Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres.Genes & development · 2017Article
- SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4.G3 (Bethesda, Md.) · 2015Article
- A Monte Carlo-based framework enhances the discovery and interpretation of regulatory sequence motifs.BMC bioinformatics · 2012Article
- Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Histone H3 localizes to the centromeric DNA in budding yeast.PLoS genetics · 2012Article
- Endogenous transcription at the centromere facilitates centromere activity in budding yeast.Current biology : CB · 2011Article
- Histone H3-variant Cse4-induced positive DNA supercoiling in the yeast plasmid has implications for a plasmid origin of a chromosome centromere.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Nonhistone Scm3 binds to AT-rich DNA to organize atypical centromeric nucleosome of budding yeast.Molecular cell · 2011Article
- The life and miracles of kinetochores.The EMBO journal · 2009Review
- Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing.BMC genomics · 2009Article
- Altered dosage and mislocalization of histone H3 and Cse4p lead to chromosome loss in Saccharomyces cerevisiae.Genetics · 2008Article
- The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-microm circle partitioning locus and promotes equal plasmid segregation.The Journal of cell biology · 2006Article
- A hitchhiker's guide to survival finally makes CENs.The Journal of cell biology · 2006Review
- Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation.Genetics · 2006Article
- The CNA1 histone of the ciliate Tetrahymena thermophila is essential for chromosome segregation in the germline micronucleus.Molecular biology of the cell · 2006Article
- Genetic and genomic analysis of the AT-rich centromere DNA element II of Saccharomyces cerevisiae.Genetics · 2005Article
- De novo kinetochore assembly requires the centromeric histone H3 variant.Molecular biology of the cell · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Each Saccharomyces cerevisiae chromosome contains a single centromere composed of three conserved DNA elements, CDE I, II, and III. The histone H3 variant, Cse4p, is an essential component of the S. cerevisiae centromere and is thought to replace H3 in specialized nucleosomes at the yeast centromere. To investigate the genetic interactions between Cse4p and centromere DNA, we measured the chromosome loss rates exhibited by cse4 cen3 double-mutant cells that express mutant Cse4 proteins and carry chromosomes containing mutant centromere DNA (cen3). When compared to loss rates for cells carrying the same cen3 DNA mutants but expressing wild-type Cse4p, we found that mutations throughout the Cse4p histone-fold domain caused surprisingly large increases in the loss of chromosomes carrying CDE I or CDE II mutant centromeres, but had no effect on chromosomes with CDE III mutant centromeres. Our genetic evidence is consistent with direct interactions between Cse4p and the CDE I-CDE II region of the centromere DNA. On the basis of these and other results from genetic, biochemical, and structural studies, we propose a model that best describes the path of the centromere DNA around a specialized Cse4p-nucleosome.
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