ReviewCurrent hypertension reports2000
Observational studies of antihypertensive medication use and compliance: is drug choice a factor in treatment adherence?
Review in Current hypertension reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Efficacy and Safety of Ultrasound Renal Denervation on Office Blood Pressure of Patients with Resistant Arterial Hypertension: A Systematic Review and Meta-analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Pooled it
- Evaluation of the dose response with valsartan and valsartan/hydrochlorothiazide in patients with essential hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2007Pooled it
- Amlodipine and valsartan combined and as monotherapy in stage 2, elderly, and black hypertensive patients: subgroup analyses of 2 randomized, placebo-controlled studies.Journal of clinical hypertension (Greenwich, Conn.) · 2007Trial
- Efficacy and safety of irbesartan/HCTZ combination therapy as initial treatment for rapid control of severe hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2006Trial
- Persistence of the antihypertensive efficacy of amlodipine and nifedipine GITS after two 'missed doses': a randomised, double-blind comparative trial in Asian patients.Journal of human hypertension · 2002Trial
- Taohong Siwu Decoction alleviates high salt-induced calcium overload and ferroptosis in vascular endothelial cells in hypertension by regulating ATF4.Frontiers in nutrition · 2025Article
- Analysis of Adherence to Antihypertensive Drugs in Chinese Patients with Hypertension: A Retrospective Analysis Using the China Health Insurance Association Database.Patient preference and adherence · 2020Article
- Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study.Medicine · 2019Observational
- Knowledge about Disease, Medication Therapy, and Related Medication Adherence Levels among Patients with Hypertension.Medicina (Kaunas, Lithuania) · 2019Observational
- Blood pressure and low-density lipoprotein cholesterol control status in Chinese hypertensive dyslipidemia patients during lipid-lowering therapy.Lipids in health and disease · 2019Article
- Nonadherence in patients with hypertensive emergency or hypertensive urgency.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Genome-wide study of resistant hypertension identified from electronic health records.PloS one · 2017Article
- Evaluation of medication adherence in Lebanese hypertensive patients.Journal of epidemiology and global health · 2016Article
- Drug attitude and adherence: a qualitative insight of patients with hypertension.Journal of young pharmacists : JYP · 2012Article
- Adherence level of antihypertensive agents in coronary artery disease.British journal of clinical pharmacology · 2010Article
- The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants.International journal of clinical practice · 2008Article
- What factors contribute to the inadequate control of elevated blood pressure?Journal of clinical hypertension (Greenwich, Conn.) · 2008Review
- The evolution of systolic blood pressure as a strong predictor of cardiovascular risk and the effectiveness of fixed-dose ARB/CCB combinations in lowering levels of this preferential target.Vascular health and risk management · 2008Review
- Article
- Initial phase of chronic medication use; patients' reasons for discontinuation.British journal of clinical pharmacology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Real-world adherence to pharmacotherapy cannot be studied in the confines of the traditional clinical trial. Thus, to better understand adherence to antihypertensive medication in actual practice, a literature search was conducted to identify observational database studies of the use of antihypertensive medication. Ten studies were identified: half studied adherence patterns after initial prescriptions to patients with a new diagnosis of hypertension, and the others evaluated antihypertensive medication use in a mix of patients with newly diagnosed or chronic hypertension. Overall, results demonstrated that adherence to treatment for hypertension in the first year is very poor. In addition, it appears that initial treatment with newer classes of drugs, such as angiotensin II antagonists, angiotensin converting enzyme inhibitors, and calcium channel blockers favors treatment adherence. This review also highlights and discusses possible under-lying factors contributing to these results and implications for physicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.