ArticleThe Journal of cell biology2000
Cytokeratins 8 and 19 in the mouse placental development.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 123 citations in OpenAlex.
- The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity.Frontiers in endocrinology · 2022Trial
- The integrated developmental stress response (ISR-DASR) shift reveals a functional transition from cellular to stem cell organismal adaptation.Scientific reports · 2026Article
- How great thou ART: biomechanical properties of oocytes and embryos as indicators of quality in assisted reproductive technologies.Frontiers in cell and developmental biology · 2024Review
- KRT18 regulates trophoblast cell migration and invasion which are essential for embryo implantation.Reproductive biology and endocrinology : RB&E · 2023Article
- Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.The EMBO journal · 2022Article
- Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Histology Atlas of the Developing Mouse Placenta.Toxicologic pathology · 2022Article
- γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis.Mucosal immunology · 2020Article
- Article
- Intestinal intermediate filament polypeptides in C. elegans: Common and isotype-specific contributions to intestinal ultrastructure and function.Scientific reports · 2020Article
- Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.Developmental cell · 2019Article
- High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype.Translational oncology · 2019Article
- Sialic acid is a critical fetal defense against maternal complement attack.The Journal of clinical investigation · 2019Article
- Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteins.F1000Research · 2019Review
- Characterization of a BAC transgenic mouse expressing Krt19-driven iCre recombinase in its digestive organs.PloS one · 2019Article
- BMP7 Induces Uterine Receptivity and Blastocyst Attachment.Endocrinology · 2017Article
- Cytokeratin 19 promoter directs the expression of Cre recombinase in various epithelia of transgenic mice.Oncotarget · 2017Article
- Review
- Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy.Nature communications · 2016Article
- A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.The Journal of cell biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
To investigate the expression and biological roles of cytokeratin 19 (K19) in development and in adult tissues, we inactivated the mouse K19 gene (Krt1-19) by inserting a bacterial beta-galactosidase gene (lacZ) by homologous recombination in embryonic stem cells, and established germ line mutant mice. Both heterozygous and homozygous mutant mice were viable, fertile, and appeared normal. By 7.5-8.0 days post coitum (dpc), heterozygous mutant embryos expressed lacZ in the notochordal plate and hindgut diverticulum, reflecting the fact that the notochord and the gut endoderm are derived from the axial mesoderm-originated cells. In the adult mutant, lacZ was expressed mainly in epithelial tissues. To investigate the possible functional cooperation and synergy between K19 and K8, we then constructed compound homozygous mutants, whose embryos died approximately 10 dpc. The lethality resulted from defects in the placenta where both K19 and K8 are normally expressed. As early as 9. 5 dpc, the compound mutant placenta had an excessive number of giant trophoblasts, but lacked proper labyrinthine trophoblast or spongiotrophoblast development, which apparently caused flooding of the maternal blood into the embryonic placenta. These results indicate that K19 and K8 cooperate in ensuring the normal development of placental tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.