ArticleThe Biochemical journal2000
3'-untranslated regions of oxidative phosphorylation mRNAs function in vivo as enhancers of translation.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
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- Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.Aging · 2013Article
- Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy.Circulation research · 2011Article
- Unusual conservation among genes encoding small secreted salivary gland proteins from a gall midge.BMC evolutionary biology · 2010Article
- Novel sequence variations in LAMA2 andSGCG genes modulating cis-acting regulatory elements and RNA secondary structure.Genetics and molecular biology · 2010Article
- Computational annotation of UTR cis-regulatory modules through Frequent Pattern Mining.BMC bioinformatics · 2009Article
- Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system.BMC genomics · 2008Article
- A message emerging from development: the repression of mitochondrial beta-F1-ATPase expression in cancer.Journal of bioenergetics and biomembranes · 2007Review
- Biogenesis and dynamics of mitochondria during the cell cycle: significance of 3'UTRs.PloS one · 2006Article
- Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.The Biochemical journal · 2004Article
- Respiratory gene expression in soybean cotyledons during post-germinative development.Plant molecular biology · 2003Article
- Assembly of the ribonucleoprotein complex containing the mRNA of the beta-subunit of the mitochondrial H+-ATP synthase requires the participation of two distal cis-acting elements and a complex set of cellular trans-acting proteins.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings have indicated that the 3'-untranslated region (3'-UTR) of the mRNA encoding the beta-catalytic subunit of the mitochondrial H(+)-ATP synthase has an in vitro translation-enhancing activity (TEA) [Izquierdo and Cuezva, Mol. Cell. Biol. (1997) 17, 5255-5268; Izquierdo and Cuezva, Biochem. J. (2000) 346, 849-855]. In the present work, we have expressed chimaeric plasmids that encode mRNA variants of green fluorescent protein in normal rat kidney and liver clone 9 cells to determine whether the 3'-UTRs of nuclear-encoded mRNAs involved in the biogenesis of mitochondria have an intrinsic TEA. TEA is found in the 3'-UTR of the mRNAs encoding the alpha- and beta-subunits of the rat H(+)-ATP synthase complex, as well as in subunit IV of cytochrome c oxidase. No TEA is present in the 3'-UTR of the somatic mRNA encoding rat mitochondrial transcription factor A. Interestingly, the TEA of the 3'-UTR of mRNAs of oxidative phosphorylation is different, depending upon the cell type analysed. These data provide the first in vivo evidence of a novel cell-specific mechanism for the control of the translation of mRNAs required in mitochondrial function.
Indexed as
Identifiers
11062063PMC1221437W1977760730What OpenQuestion holds
Registered trials
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