ArticleThe Journal of physiology2000
Descending inhibitory reflexes involve P2X receptor-mediated transmission from interneurons to motor neurons in guinea-pig ileum.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 75 citations in OpenAlex.
- Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission.Neuropharmacology · 2015Article
- Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons.Histochemistry and cell biology · 2015Article
- Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014Review
- Article
- Effects of ischemia and reperfusion on P2X2 receptor expressing neurons of the rat ileum enteric nervous system.Digestive diseases and sciences · 2011Article
- Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program.PloS one · 2011Article
- Effects of protein deprivation and re-feeding on P2X2 receptors in enteric neurons.World journal of gastroenterology · 2010Article
- Cross-inhibition between nicotinic acetylcholine receptors and P2X receptors in myenteric neurons and HEK-293 cells.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Electrochemical monitoring of nitric oxide released by myenteric neurons of the guinea pig ileum.Neurogastroenterology and motility · 2008Article
- Purinergic receptors and synaptic transmission in enteric neurons.Purinergic signalling · 2008Article
- Purinergic mechanisms in the control of gastrointestinal motility.Purinergic signalling · 2008Article
- Synaptic transmission at functionally identified synapses in the enteric nervous system: roles for both ionotropic and metabotropic receptors.Current neuropharmacology · 2007Article
- Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin.Histochemistry and cell biology · 2005Article
- Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum.The Journal of physiology · 2004Article
- ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum.The Journal of physiology · 2004Article
- Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome.British journal of pharmacology · 2004Review
- P2X2 and P2X3 purinoceptors in the rat enteric nervous system.Histochemistry and cell biology · 2004Article
- P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine.The Journal of physiology · 2003Article
- Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit.The Journal of physiology · 2003Article
- A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon.The Journal of physiology · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of P2X receptors in descending inhibitory reflexes evoked by distension or mucosal distortion in the guinea-pig ileum was studied using intracellular recording from the circular muscle in a two-chambered organ bath. This allowed separate superfusion of the sites of reflex stimulation and recording, thereby allowing drugs to be selectively applied to different parts of the reflex pathway. Inhibitory junction potentials (IJPs) evoked by electrical field stimulation (EFS) in the recording chamber were compared with those evoked during reflexes to control for effects of P2 receptor antagonists on neuromuscular transmission. The P2 receptor antagonists suramin (100 microM) and pyridoxal phosphate-6-azophenyl-2',4'-disulphonic acid (10 and 60 microM; PPADS), when added to the recording chamber, depressed reflexly evoked IJPs significantly more than those evoked by EFS. In particular, 10 microM PPADS depressed IJPs evoked by distension or mucosal distortion by about 50 %, but had little effect on IJPs evoked by EFS. Blockade of synaptic transmission in the stimulation chamber with a low Ca2+-high Mg2+ solution depressed, but did not abolish, IJPs evoked by distension. The residual reflex IJPs were unaffected by PPADS (10 microM), hyoscine (1 microM), hyoscine plus hexamethonium (200 microM), or hysocine plus hexamethonium plus PPADS in the recording chamber. We conclude that P2X receptors are important for synaptic transmission from descending interneurons to inhibitory motor neurons in descending inhibitory reflex pathways of guinea-pig ileum. Transmission from anally directed axons of distension-sensitive intrinsic sensory neurons to inhibitory motor neurons is unlikely to involve P2X, muscarinic or nicotinic receptors.
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