ArticleJournal of clinical microbiology2000
Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02367222 (An Observational Retrospective Database Analysis to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Retrospective Database Analysis to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada
Who cites it
10 citing papers in PubMed, 52 citations in OpenAlex.
- The Probable Infectious Origin of Multiple Sclerosis.NeuroSci · 2023Review
- Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or PulmonaryMicroorganisms · 2020Review
- Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders.Interdisciplinary perspectives on infectious diseases · 2010Article
- Article
- Real time PCR for detection of Chlamydophila pneumoniae in peripheral blood mononuclear cells of patients with multiple sclerosis.Journal of neurology · 2007Article
- Hit-Hit and hit-Run: viruses in the playing field of multiple sclerosis.Current neurology and neuroscience reports · 2003Review
- Detection of Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis by combination of cell culture and PCR: no evidence for possible association.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2003Article
- Inclusion fluorescent-antibody test as a screening assay for detection of antibodies to Chlamydia pneumoniae.Clinical and diagnostic laboratory immunology · 2002Article
- Development and evaluation of real-time PCR-based fluorescence assays for detection of Chlamydia pneumoniae.Journal of clinical microbiology · 2002Article
- Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimens.Journal of clinical microbiology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.