ArticleJournal of clinical microbiology2000
Molecular and pathogenic characterization of Borrelia burgdorferi sensu lato isolates from Spain.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
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- Occurrence and Identification ofPathogens (Basel, Switzerland) · 2021Article
- Molecular identification of Borrelia spirochetes in questing Ixodes ricinus from northwestern Spain.Parasites & vectors · 2017Article
- Abundance of Ixodes ricinus and prevalence of Borrelia burgdorferi s.l. in the nature reserve Siebengebirge, Germany, in comparison to three former studies from 1978 onwards.Parasites & vectors · 2012Article
- Borrelia burgdorferi sensu lato species in Europe induce diverse immune responses against C6 peptides in infected mice.Clinical and vaccine immunology : CVI · 2009Article
- Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human.BMC research notes · 2009Article
- Fine-scale phylogeographic structure of Borrelia lusitaniae revealed by multilocus sequence typing.PloS one · 2008Article
- Tick-borne zoonotic bacteria in wild and domestic small mammals in northern Spain.Applied and environmental microbiology · 2007Article
- Rickettsia monacensis and human disease, Spain.Emerging infectious diseases · 2007Article
- Identification of a new Borrelia species among small mammals in areas of northern Spain where Lyme disease is endemic.Applied and environmental microbiology · 2005Article
- Hosts and pathogen detection for immature stages of Ixodes ricinus (Acari: Ixodidae) in North-Central Spain.Experimental & applied acarology · 2005Article
- Screening of the prevalence of antibodies to Borrelia burgdorferi in Madrid province, Spain.European journal of epidemiology · 2004Article
- PCR-reverse line blot typing method underscores the genomic heterogeneity of Borrelia valaisiana species and suggests its potential involvement in Lyme disease.Journal of clinical microbiology · 2003Article
- Relapsing fever-like spirochetes infecting European vector tick of Lyme disease agent.Emerging infectious diseases · 2003Article
- Association of Borrelia garinii and B. valaisiana with songbirds in Slovakia.Applied and environmental microbiology · 2003Article
- Habitat-specific diversity of Borrelia burgdorferi sensu lato in Europe, exemplified by data from Latvia.Applied and environmental microbiology · 2003Article
- Prevalence of Borrelia burgdorferi species and identification of Borrelia valaisiana in questing Ixodes ricinus in the Lyon region of France as determined by polymerase chain reaction-restriction fragment length polymorphism.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fifteen Borrelia burgdorferi sensu lato isolates from questing ticks and skin biopsy specimens from erythema migrans patients in three different areas of Spain were characterized. Four different genospecies were found (nine Borrelia garinii, including the two human isolates, three B. burgdorferi sensu stricto, two B. valaisiana, and one B. lusitaniae), showing a diverse spectrum of B. burgdorferi sensu lato species. B. garinii isolates were highly variable in terms of pulsed-field gel electrophoresis pattern and OspA serotype, with four of the seven serotypes described. One of the human isolates was OspA serotype 5, the same found in four of seven tick isolates. The second human isolate was OspA serotype 3, which was not present in ticks from the same area. Seven B. garinii isolates were able to disseminate through the skin of C3H/HeN mice and to cause severe inflammation of joints. One of the two B. valaisiana isolates also caused disease in mice. Only one B. burgdorferi sensu stricto isolate was recovered from the urinary bladder. One isolate each of B. valaisiana and B. lusitaniae were not able to disseminate through the skin of mice or to infect internal organs. In summary, there is substantial diversity in the species and in the pathogenicity of B. burgdorferi sensu lato in areas in northern Spain where Lyme disease is endemic.
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