ArticleJournal of clinical microbiology2000
Discrimination between clinically relevant and nonrelevant Acanthamoeba strains isolated from contact lens- wearing keratitis patients in Austria.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Global prevalence of potentially pathogenic free-living amoebae in sewage and sewage-related environments-systematic review with meta-analysis.Parasitology research · 2024Pooled it
- Medical interventions for acanthamoeba keratitis.The Cochrane database of systematic reviews · 2015Pooled it
- Modeling Fungal and Amoebic Infections: Co-culture Approaches to Study MIF's Role in Infection-Induced Inflammatory Responses.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Learning from the rDNA Operon: A Reanalysis of theMicroorganisms · 2024Article
- Chitosan nanoparticles improve the effectivity of miltefosine against Acanthamoeba.PLoS neglected tropical diseases · 2024Article
- Proteases of Acanthamoeba.Parasitology research · 2023Review
- Experimental keratitis induced in rat by Acanthamoeba from distinct morphological groups/genotypes: a histological and immunohistochemical evaluation.Parasitology research · 2023Article
- The Status of Molecular Analyses of Isolates ofMicroorganisms · 2023Review
- Detection and Identification ofJournal of clinical microbiology · 2021Article
- An annotated checklist of the eukaryotic parasites of humans, exclusive of fungi and algae.ZooKeys · 2021Article
- Article
- Comparative in vitro effectiveness of a novel contact lens multipurpose solution on Acanthamoeba castellanii.Journal of ophthalmic inflammation and infection · 2018Article
- Genotyping ofThe Indian journal of medical research · 2018Article
- Assessment of the antiprotozoal activity of Pulicaria inuloides extracts, an Algerian medicinal plant: leishmanicidal bioguided fractionation.Parasitology research · 2018Article
- Acanthamoeba-mediated cytopathic effect correlates with MBP and AhLBP mRNA expression.Parasites & vectors · 2017Article
- Characterization of extracellular proteases of Acanthamoeba genotype T4 isolated from different sources in Iran.Parasitology research · 2017Article
- In vivo CNS infection model of Acanthamoeba genotype T4: the early stages of infection lack presence of host inflammatory response and are a slow and contact-dependent process.Parasitology research · 2017Article
- Repertoire of free-living protozoa in contact lens solutions.BMC ophthalmology · 2016Article
- Monitoring of Waterborne Parasites in Two Drinking Water Treatment Plants: A Study in Sarawak, Malaysia.International journal of environmental research and public health · 2016Article
- Distribution of Acanthamoeba Genotypes Isolated from Recreational and Therapeutic Geothermal Water Sources in Southwestern Iran.Environmental health insights · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eighteen cases of Acanthamoeba-associated keratitis among contact lens wearers seen at the Department of Ophthalmology, Karl-Franzens-University, Graz, Austria, between 1996 and 1999 are reviewed. The amoebae were proven to be the causative agents in three patients. The aim of our study was to discriminate between clinically relevant and nonrelevant isolates and to assess the relatedness of the isolates to published strains. Altogether, 20 strains of free-living amoebae, including 15 Acanthamoeba strains, 3 Vahlkampfia strains, and 2 Hartmannella strains, were isolated from clinical specimens. The virulent Acanthamoeba strains were identified as A. polyphaga and two strains of A. hatchetti. To our knowledge this is the first determination of keratitis-causing Acanthamoeba strains in Austria. Clinically relevant isolates differed markedly from nonrelevant isolates with respect to their physiological properties. 18S ribosomal DNA sequence types were determined for the three physiologically most-divergent strains including one of the keratitis-causing strains. This highly virulent strain exhibited sequence type T6, a sequence type not previously associated with keratitis. Sequence data indicate that Acanthamoeba strains causing keratitis as well as nonpathogenic strains of Acanthamoeba in Austria are most closely related to published strains from other parts of the world. Moreover, the results of our study support the assumption that pathogenicity in Acanthamoeba is a distinct capability of certain strains and not dependent on appropriate conditions for the establishment of an infection.
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