ArticleThe EMBO journal2000
Osmotic stress response in Dictyostelium is mediated by cAMP.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of prey quality through the life cycle of the social amoeba Dictyostelium discoideum.BMC molecular and cell biology · 2026Article
- Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling inCells · 2025Review
- Formation of Cytoplasmic Actin-Cofilin Rods is Triggered by Metabolic Stress and Changes in Cellular pH.Frontiers in cell and developmental biology · 2021Article
- Evolution of multicellularity in Dictyostelia.The International journal of developmental biology · 2019Review
- Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1.Antimicrobial agents and chemotherapy · 2017Article
- Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.Physical review. E · 2017Article
- The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.Journal of molecular biology · 2015Review
- Osmosensing and osmoregulation in unicellular eukaryotes.World journal of microbiology & biotechnology · 2015Review
- The arrestin-domain containing protein AdcA is a response element to stress.Cell communication and signaling : CCS · 2013Article
- Application of universal stress proteins in probing the dynamics of potent degraders in complex terephthalate metagenome.BioMed research international · 2013Article
- Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment.Journal of the Royal Society, Interface · 2011Article
- Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Article
- cAMP controls cytosolic Ca2+ levels in Dictyostelium discoideum.BMC cell biology · 2005Article
- Adenylyl cyclase G is activated by an intramolecular osmosensor.Molecular biology of the cell · 2004Article
- The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum and its possible involvement in development.Eukaryotic cell · 2004Article
- Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton.Molecular biology of the cell · 2003Article
- Complete genome sequence and analysis of Wolinella succinogenes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Hisactophilin is involved in osmoprotection in Dictyostelium.BMC biochemistry · 2002Article
- cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.Journal of muscle research and cell motility · 2002Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DokA, a homolog of bacterial hybrid histidine kinases, is essential for hyperosmotic stress resistance in Dictyostelium: We show that a transient intracellular cAMP signal, dependent on the presence of DokA, is generated in response to an osmotic shock. This variation of cAMP levels contributes to survival under hypertonic conditions. In contrast to the low cAMP levels observed in dokA(-) strains, overexpression of the receiver domain of DokA causes an increase in cAMP levels, resulting in a rapidly developing phenotype. We present biochemical and cell biological data indicating that the DokA receiver domain is a dominant-negative regulator of a phosphorelay, which controls the intracellular cAMP phosphodiesterase RegA. The activity of the DokA receiver domain depends on a conserved aspartate, mutation of which reverses the developmental phenotype, as well as the deregulation of cAMP metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.