ReviewNeurochemical research2000
Signaling events during swelling and regulatory volume decrease.
Review in Neurochemical research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration.Veterinary sciences · 2026Review
- Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss.Scientific reports · 2024Article
- The Important Role of Ion Transport System in Cervical Cancer.International journal of molecular sciences · 2021Review
- The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases.Aging and disease · 2019Review
- Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force.Biophysical journal · 2018Article
- Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus.Current topics in membranes · 2018Article
- Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish.eLife · 2017Article
- The role of ion channels in malignant brain tumors.Journal of neuro-oncology · 2015Review
- K-Cl cotransporters, cell volume homeostasis, and neurological disease.Trends in molecular medicine · 2015Review
- Volume-dependent osmolyte efflux from neural tissues: regulation by G-protein-coupled receptors.Journal of neurochemistry · 2008Review
- Regulatory volume decrease after swelling induced by urea in fibroblasts: prominent role of organic osmolytes.Molecular and cellular biochemistry · 2007Article
- Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.Neurochemical research · 2007Article
- TRPM7 channel is sensitive to osmotic gradients in human kidney cells.The Journal of physiology · 2007Article
- Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices.Lab on a chip · 2007Article
- Article
- Effects of phospholemman expression on swelling-activated ion currents and volume regulation in embryonic kidney cells.Neurochemical research · 2004Article
- Taurine as a modulator of excitatory and inhibitory neurotransmission.Neurochemical research · 2004Article
- The anion exchanger as an osmolyte channel in the skate erythrocyte.Neurochemical research · 2004Article
- Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Searching for mechanisms of N-methyl-D-aspartate-induced glutathione efflux in organotypic hippocampal cultures.Neurochemical research · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain cell swelling compromises neuronal function and survival by the risk of generation of ischemia episodes as compression of small vessels occurs due to the limits to expansion imposed by the rigid skull. External osmolarity reductions or intracellular accumulation of osmotically active solutes result in cell swelling which can be counteracted by extrusion of osmolytes through specific efflux pathways. Characterization of these pathways has received considerable attention, and there is now interest in the understanding of the intracellular signaling events involved in their activation and regulation. Calcium and calmodulin, phosphoinositides and cAMP may act as second messengers, carrying the information about a cell volume change into signaling enzymes. Small GTPases, protein tyrosine kinases and phospholipases, also appear to be part of the signaling cascades ultimately modulating the osmolyte efflux pathways. This review focus on i) the influence of hyposmotic and isosmotic swelling on these signaling events and molecules and ii) the effects of manipulating their function on the osmolyte fluxes, particularly K+, CI- and amino acids, and on the consequent efficiency of cell volume adjustment.
Indexed as
Identifiers
11059803What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.