ArticleNucleic acids research2000
The yeast CDP1 gene encodes a triple-helical DNA-binding protein.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Three- and four-stranded nucleic acid structures and their ligands.RSC chemical biology · 2025Review
- Detection of Protein-Nucleic Acid Interaction by Electrophoretic Mobility Shift Assay.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Delineating the mechanism of fragility at BCL6 breakpoint region associated with translocations in diffuse large B cell lymphoma.Cellular and molecular life sciences : CMLS · 2024Article
- Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.Genome research · 2020Article
- Structure of transcribing RNA polymerase II-nucleosome complex.Nature communications · 2018Article
- The Mapping of Predicted Triplex DNA:RNA in theG3 (Bethesda, Md.) · 2017Article
- saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.Cell research · 2016Article
- Triple helix-interacting proteins and cancer.OA molecular oncology · 2013Article
- DNA triplex structures in neurodegenerative disorder, Friedreich's ataxia.Journal of biosciences · 2012Review
- Review
- Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases.Journal of nucleic acids · 2011Article
- Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment.The Journal of biological chemistry · 2010Article
- Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions.Nature protocols · 2007Article
- New insights into DNA triplexes: residual twist and radial difference as measures of base triplet non-isomorphism and their implication to sequence-dependent non-uniform DNA triplex.Nucleic acids research · 2005Article
- The capacity to form H-DNA cannot substitute for GAGA factor binding to a (CT)n*(GA)n regulatory site.Nucleic acids research · 2003Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of triple-helical DNA has been implicated in several cellular processes, including transcription, replication and recombination. While there is no direct evidence for triplexes in vivo, cellular proteins that specifically recognize triplex DNA have been described. Using a purine-motif triplex probe and southwestern library screening, we isolated five independent clones expressing the same C-terminal 210 amino acids of the Saccharomyces cerevisiae protein Cdp1p fused with beta-galactosidase. In electrophoretic mobility shift assays, recombinant Cdp1pDelta1-867 bound Pu-motif triplex DNAs with high affinity (K:(d) approximately 5 nM) and bound Py-motif triplex, duplex and single-stranded DNAs with far lower affinity (0.5-5.0 microM). Genetic analyses revealed that the CDP1 gene product was required for proper chromosome segregation. The possible involvement of triplex DNA in this process is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.