ArticleArthritis research2000
The role of X-chromosome inactivation in female predisposition to autoimmunity.
Article in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 95 citations in OpenAlex.
- Analysis of influencing factors on Turner syndrome combined with autoimmune thyroid disease.Frontiers in endocrinology · 2025Article
- Haematopoietic stem cell-derived immune cells have reduced X chromosome inactivation skewing in systemic lupus erythematosus.Annals of the rheumatic diseases · 2024Article
- 47XXY and 47XXX in Scleroderma and Myositis.ACR open rheumatology · 2022Article
- Preferential X Chromosome Inactivation as a Mechanism to Explain Female Preponderance in Myasthenia Gravis.Genes · 2022Article
- Distinct hepatic immunological patterns are associated with the progression or inhibition of hepatocellular carcinoma.Cell reports · 2022Article
- Immune-Related Adverse Events in PD-1 Treated Melanoma and Impact Upon Anti-Tumor Efficacy: A Real World Analysis.Frontiers in oncology · 2021Article
- COVID-19 as an Acute Inflammatory Disease.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
- Autoimmune Thyroid Disease in Specific Genetic Syndromes in Childhood and Adolescence.Frontiers in endocrinology · 2020Review
- SeXX Matters in Multiple Sclerosis.Frontiers in neurology · 2020Review
- Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality.Frontiers in immunology · 2020Review
- Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.Nature communications · 2019Article
- Autoimmune diseases in Turner syndrome: an overview.Acta bio-medica : Atenei Parmensis · 2019Review
- Intragenomic Conflict and Immune Tolerance: Do Selfish X-Linked Alleles Drive Skewed X Chromosome Inactivation?Genome biology and evolution · 2018Article
- RNA-Sequencing Gene Expression Profiling of Orbital Adipose-Derived Stem Cell Population Implicate HOX Genes and WNT Signaling Dysregulation in the Pathogenesis of Thyroid-Associated Orbitopathy.Investigative ophthalmology & visual science · 2017Article
- [Sex-specific differences of the immune system].Zeitschrift fur Rheumatologie · 2014Review
- A case associated with comorbidities among cerebral infarction, idiopathic thrombocytopenic purpura, and triple x syndrome.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2014Article
- Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.Investigative ophthalmology & visual science · 2014Review
- Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency.Journal of autoimmunity · 2012Article
- The role of epigenetic mechanisms and processes in autoimmune disorders.Biologics : targets & therapy · 2012Article
- The genetic basis of graves' disease.Current genomics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to inadequate thymic deletion. Using a DNA methylation assay, we have examined the X-chromosome inactivation patterns in peripheral blood from normal females (n = 30), female patients with a variety of autoimmune diseases (n = 167). No differences between patients and controls were observed. However, locally skewed X-chromosome inactivation may exist in the thymus, and therefore the underlying hypothesis remains to be disproved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.