ArticleArthritis research2000
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4.
Article in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 100 citations in OpenAlex.
- Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes.Experimental & molecular medicine · 2022Article
- Review
- IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine collagen-induced arthritis.PloS one · 2015Article
- Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5.SpringerPlus · 2013Article
- Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Molecular targeting of hepatocyte growth factor by an antagonist, NK4, in the treatment of rheumatoid arthritis.Arthritis research & therapy · 2013Article
- Regulation and function of epithelial secreted phospholipase A2 group X in asthma.American journal of respiratory and critical care medicine · 2013Article
- Gene Therapy for Cartilage Repair.Cartilage · 2011Review
- Article
- Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model.PloS one · 2011Article
- Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice.PloS one · 2010Article
- The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.Journal of neurochemistry · 2010Article
- Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models.Arthritis and rheumatism · 2009Article
- Perspectives on the use of gene therapy for chronic joint diseases.Current gene therapy · 2008Review
- Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis.Immunology · 2008Article
- Gene therapy for arthritis.Modern rheumatology · 2008Review
- Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis.Gene therapy · 2007Article
- Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?Arthritis research & therapy · 2004Review
- The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen.Gene therapy · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA). Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of arthritis and joint swelling compared with saline- and adenoviral control groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind ankle joints resulted in a decrease in disease severity in the untreated front paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4 resulted in a significant reduction in the severity of early-stage arthritis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.