ArticleArthritis research2000
Apoptosis and p53 expression in rat adjuvant arthritis.
Article in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Anti-arthritic effect of chicken embryo tissue hydrolyzate against adjuvant arthritis in rats (X-ray microtomographic and histopathological analysis).Food science & nutrition · 2021Article
- Effect of electroacupuncture at the ST36 and GB39 acupoints on apoptosis by regulating the p53 signaling pathway in adjuvant arthritis rats.Molecular medicine reports · 2019Article
- p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis.Arthritis research & therapy · 2016Article
- Synovial tissue hypoxia and inflammation in vivo.Annals of the rheumatic diseases · 2010Article
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis.Immunological reviews · 2010Review
- p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage.Annals of the rheumatic diseases · 2005Article
- Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?Arthritis research & therapy · 2004Review
- p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.Annals of the rheumatic diseases · 2003Article
- Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis.The American journal of pathology · 2002Article
- Rheumatoid arthritis viewed using a headache paradigm.Arthritis research · 2000Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STATEMENT OF
findingsThe kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick end-labeling (TUNEL)-positive cells were detected during the early phases of AA, but on day 23 (chronic arthritis) the percentage of TUNEL-positive cells was significantly increased. Expression of p53 in synovial tissue gradually increased from days 5-23, which was markedly higher than p53 levels in rheumatoid arthritis (RA) synovium. Significant apoptosis only occurs late in rat AA and is concordant with marked p53 overexpression, making it useful model for testing proapoptotic therapies, but rat AA is not the best model for p53 gene therapy because dramatic p53 overexpression occurs in the latter stages of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.