ArticleThe Journal of general physiology2000
Opening and closing of KCNKO potassium leak channels is tightly regulated.
Article in The Journal of general physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Carotid Body Type-I Cells Under Chronic Sustained Hypoxia: Focus on Metabolism and Membrane Excitability.Frontiers in physiology · 2018Article
- Article
- Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain.The Journal of physiology · 2016Article
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure-a suggested HPNS partial mechanism.Frontiers in cellular neuroscience · 2014Article
- A Role for K2P Channels in the Operation of Somatosensory Nociceptors.Frontiers in molecular neuroscience · 2012Article
- K2P potassium channels, mysterious and paradoxically exciting.Science signaling · 2011Article
- Gating the pore of potassium leak channels.European biophysics journal : EBJ · 2009Review
- A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics.The Journal of general physiology · 2009Article
- Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling.Nature structural & molecular biology · 2009Article
- Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Intrinsic noise in cultured hippocampal neurons: experiment and modeling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Carboxyl tail prevents yeast K(+) channel closure: proposal of an integrated model of TOK1 gating.Biophysical journal · 2002Article
- Kcnkø: single, cloned potassium leak channels are multi-ion pores.Biophysical journal · 2001Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potassium-selective leak channels control neuromuscular function through effects on membrane excitability. Nonetheless, their existence as independent molecular entities was established only recently with the cloning of KCNKO from Drosophila melanogaster. Here, the operating mechanism of these 2 P domain leak channels is delineated. Single KCNKO channels switch between two long-lived states (one open and one closed) in a tenaciously regulated fashion. Activation can increase the open probability to approximately 1, and inhibition can reduce it to approximately 0.05. Gating is dictated by a 700-residue carboxy-terminal tail that controls the closed state dwell time but does not form a channel gate; its deletion (to produce a 300-residue subunit with two P domains and four transmembrane segments) yields unregulated leak channels that enter, but do not maintain, the closed state. The tail integrates simultaneous input from multiple regulatory pathways acting via protein kinases C, A, and G.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.