ArticleBiophysical journal2000
Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 109 citations in OpenAlex.
- Protein overexpression can induce the elongation of cell membrane nanodomains.Biophysical journal · 2023Article
- Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development.Molecules (Basel, Switzerland) · 2021Review
- Studying Interactions between 2'-O-Me-Modified Inhibitors and MicroRNAs Utilizing Microscale Thermophoresis.Molecular therapy. Nucleic acids · 2019Article
- Origin and prediction of free-solution interaction studies performed label-free.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Surface plasmon resonance: a versatile technique for biosensor applications.Sensors (Basel, Switzerland) · 2015Review
- High Efficacy but Low Potency of δ-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments.PloS one · 2015Article
- High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.The Journal of biological chemistry · 2012Article
- Broadband plasmon waveguide resonance spectroscopy for probing biological thin films.Applied spectroscopy · 2009Article
- Cellular assays as portals to seven-transmembrane receptor-based drug discovery.Nature reviews. Drug discovery · 2009Review
- Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells.Analytical biochemistry · 2009Article
- What do diffusion measurements tell us about membrane compartmentalisation? Emergence of the role of interprotein interactions.Journal of chemical biology · 2008Article
- Reconstitution of rhodopsin into polymerizable planar supported lipid bilayers: influence of dienoyl monomer structure on photoactivation.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.European journal of pharmacology · 2008Article
- Changes of the membrane lipid organization characterized by means of a new cholesterol-pyrene probe.Biophysical journal · 2007Article
- Plasmon-waveguide resonance (PWR) spectroscopy for directly viewing rates of GPCR/G-protein interactions and quantifying affinities.Current opinion in pharmacology · 2007Review
- Article
- New paradigms and tools in drug design for pain and addiction.The AAPS journal · 2006Review
- Article
- Homology modeling of opioid receptor-ligand complexes using experimental constraints.The AAPS journal · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Structural changes accompanying the binding of ligands to the cloned human delta-opioid receptor immobilized in a solid-supported lipid bilayer have been investigated using coupled plasmon-waveguide resonance spectroscopy. This highly sensitive technique directly monitors mass density, conformation, and molecular orientation changes occurring in anisotropic thin films and allows direct determination of binding constants. Although both agonist binding and antagonist binding to the receptor cause increases in molecular ordering within the proteolipid membrane, only agonist binding induces an increase in thickness and molecular packing density of the membrane. This is a consequence of mass movements perpendicular to the plane of the bilayer occurring within the lipid and receptor components. These results are consistent with models of receptor function that involve changes in the orientation of transmembrane helices.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.