ArticleBiophysical journal2000
A cell-based constitutive relation for bio-artificial tissues.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- A comprehensive framework for computational modeling of growth and remodeling in tissue-engineered soft collagenous materials.Biomechanics and modeling in mechanobiology · 2025Article
- The fibrous character of pericellular matrix mediates cell mechanotransduction.Journal of the mechanics and physics of solids · 2023Article
- Multiscale mechanobiology: Coupling models of adhesion kinetics and nonlinear tissue mechanics.Biophysical journal · 2022Article
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- Helical nanofiber yarn enabling highly stretchable engineered microtissue.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix.Journal of the mechanical behavior of biomedical materials · 2018Article
- Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.Scientific reports · 2016Article
- Remodeling by fibroblasts alters the rate-dependent mechanical properties of collagen.Acta biomaterialia · 2016Article
- A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells.Interface focus · 2016Article
- Tissue constructs: platforms for basic research and drug discovery.Interface focus · 2016Article
- Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells.PloS one · 2015Article
- Article
- The role of mechanics in actin stress fiber kinetics.Experimental cell research · 2013Review
- A multiscale approach to modeling the passive mechanical contribution of cells in tissues.Journal of biomechanical engineering · 2013Article
- Article
- Large-scale mechanical properties of Xenopus embryonic epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Measurement of contractile forces generated by individual fibroblasts on self-standing fiber scaffolds.Biomedical microdevices · 2011Article
- Diffusion of MMPs on the surface of collagen fibrils: the mobile cell surface-collagen substratum interface.PloS one · 2011Article
- On the biomechanical function of scaffolds for engineering load-bearing soft tissues.Acta biomaterialia · 2010Review
- Whole cell mechanics of contractile fibroblasts: relations between effective cellular and extracellular matrix moduli.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By using a combination of continuum and statistical mechanics we derive an integral constitutive relation for bio-artificial tissue models consisting of a monodisperse population of cells in a uniform collagenous matrix. This constitutive relation quantitatively models the dependence of tissue stress on deformation history, and makes explicit the separate contribution of cells and matrix to the mechanical behavior of the composite tissue. Thus microscopic cell mechanical properties can be deduced via this theory from measurements of macroscopic tissue properties. A central feature of the constitutive relation is the appearance of "anisotropy tensors" that embody the effects of cell orientation on tissue mechanics. The theory assumes that the tissues are stable over the observation time, and does not in its present form allow for cell migration, reorientation, or internal remodeling. We have compared the predictions of the theory to uniaxial relaxation tests on fibroblast-populated collagen matrices (FPMs) and find that the experimental results generally support the theory and yield values of fibroblast contractile force and stiffness roughly an order of magnitude smaller than, and viscosity comparable to, the corresponding properties of active skeletal muscle. The method used here to derive the tissue constitutive equation permits more sophisticated cell models to be used in developing more accurate representations of tissue properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.