ArticleBiophysical journal2000
Models of post-translational protein translocation.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Quantifying the role of chaperones in protein translocation by computational modeling.Frontiers in molecular biosciences · 2015Article
- BiP clustering facilitates protein folding in the endoplasmic reticulum.PLoS computational biology · 2014Article
- Simulating the pulling of stalled elongated peptide from the ribosome by the translocon.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Computer simulation of polypeptide translocation through a nanopore.Journal of molecular modeling · 2005Article
- Molt cycle-dependent molecular chaperone and polyubiquitin gene expression in lobster.Cell stress & chaperones · 2003Article
- The brownian ratchet and power stroke models for posttranslational protein translocation into the endoplasmic reticulum.Biophysical journal · 2002Article
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Authors and funding
1 author.
Funding
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Abstract
Organellar Hsp-70 is required for post-translational translocation into the endoplasmic reticulum and mitochondria. The functional role played by Hsp-70 is unknown. However, two operating principles have been suggested. The power stroke model proposes that Hsp-70 undergoes a conformational change, which pulls the precursor protein through the translocation pore, whereas, in the Brownian ratchet model, the role of Hsp-70 is simply to block backsliding through the pore. A mathematical analysis of both mechanisms is presented and reveals that qualitative differences between the models occur in the behavior of the mean velocity and effective diffusion coefficient as a function of Hsp-70 concentration. An experimental method is proposed for measuring these two quantities that only relies on current experimental techniques.
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