ArticleDigestive diseases and sciences2000
Nitric oxide and superoxide anion in low-grade esophagitis induced by acid and pepsin in rabbits.
Article in Digestive diseases and sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial functions.Digestive diseases and sciences · 2005Trial
- The protective effect of erythropoietin on the acute phase of corrosive esophageal burns in a rat model.Pediatric surgery international · 2010Article
- iNOS expression in oral and gastrointestinal tract mucosa.Digestive diseases and sciences · 2008Review
- Reactive oxygen species and chemokines: are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?World journal of gastroenterology · 2008Article
- Inflammation and oxidative stress in gastroesophageal reflux disease.Journal of clinical biochemistry and nutrition · 2007Article
- Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus.World journal of gastroenterology · 2005Article
- Prevention by rebamipide of acute reflux esophagitis in rats.Digestive diseases and sciences · 2005Article
- Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus.World journal of gastroenterology · 2005Article
- Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis.Inflammation · 2003Article
- Analysis of mucosal stress response in acid-induced esophagitis in opossum.Digestive diseases and sciences · 2002Article
- Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits.Digestive diseases and sciences · 2001Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that free radicals are involved in esophagitis. To study the role and potential interaction of superoxide anion and nitric oxide (NO) in low-grade esophagitis, we perfused acidified pepsin (30 min every 12 hr) for seven days in rabbits treated with different agents to modulate the generation of these radicals. Measurements included macroscopic and microscopic damage, superoxide anion generation, mucosal nitric oxide synthase activity, and peroxynitrite formation. Low-grade esophagitis was associated with increased nitric oxide synthase mucosal activity and mucosal damage was dose-dependently increased by treatment with the NO synthase inhibitor NG-nitro-L-arginine. Superoxide anion was scarcely generated in the mucosa, but this was not accompanied by any change in the activity of mucosal superoxide dismutase. Treatment with superoxide dismutase did not improve mucosal damage. Generation of peroxynitrites was not detected. In conclusion, nitric oxide is involved in the mucosal defense of the esophagus against acid- and pepsin-induced damage. Superoxide anion generation seems irrelevant in the induction of low-grade esophagitis and not sufficient to interact with nitric oxide to generate measurable mucosal peroxynitrite radicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.